Jonathan Rothberg

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(Created page with "<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><b>Jonathan M. Rothberg</b> (born 1963) is a...")
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><b>Jonathan M. Rothberg</b>&nbsp;(born 1963) is an American scientist and entrepreneur.</p>
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<div>Jonathan M. Rothberg (born 1963) is an American scientist and entrepreneur.</div>
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<div>&nbsp;</div>
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<div>Early life</div>
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<h2 style="background-image: none; margin: 0px 0px 0.6em; overflow: hidden; padding: 0px; border: none; font-size: 12px; display: inline;">Contents</h2>
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<div>&nbsp;</div>
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&nbsp;<span class="toctoggle" style="-webkit-user-select: none; font-size: 11.199999809265137px;">&nbsp;[<a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#" class="internal" id="togglelink" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">show</a>]&nbsp;</span></div>
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<div>Jonathan was born in New Haven, Connecticut the son of Lillian and Dr. Henry Rothberg a chemical engineer. &nbsp;Prior to Jonathan's birth, Lillian and Dr. Henry Rothberg founded Laticrete International, Inc. a family-owned, global manufacturer of products for the installation of tile and stone. &nbsp;Jonathan's family established the foundation for his scientific career; early on, he was heavily influenced by his father's engineering background and problem solving abilities, as well as his mother's belief that he would &quot;do good science.&quot;[1]</div>
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<div>&nbsp;</div>
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<p>&nbsp;</p>
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<div>Education and scientific career</div>
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<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Early_life">Early life</span><span class="mw-editsection mw-editsection-expanded" style="-webkit-user-select: none; font-size: small; margin-left: 1em; vertical-align: baseline; line-height: 1em; display: inline-block; white-space: nowrap; padding-right: 0.25em; unicode-bidi: -webkit-isolate; direction: ltr;"><span class="mw-editsection-bracket" style="margin-left: -0.25em; margin-right: 0.25em; color: rgb(85, 85, 85);">[</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;action=edit&amp;section=1&amp;editintro=Template:BLP_editintro" title="Edit section: Early life" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit source</a><span class="mw-editsection-divider" style="color: rgb(85, 85, 85);">&nbsp;|&nbsp;</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;veaction=edit&amp;section=1&amp;editintro=Template:BLP_editintro" title="Edit section: Early life" class="mw-editsection-visualeditor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit<span class="ve-tabmessage-appendix" style="font-size: 0.7em; vertical-align: top; line-height: 1.43em; padding-left: 0.5em; background-image: none !important; display: inline !important;">beta</span></a><span class="mw-editsection-bracket" style="margin-right: -0.25em; margin-left: 0.25em; color: rgb(85, 85, 85);">]</span></span></h2>
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<div>&nbsp;</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Jonathan was born in&nbsp;<a href="http://en.wikipedia.org/wiki/New_Haven,_Connecticut" title="New Haven, Connecticut" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">New Haven, Connecticut</a>&nbsp;the son of Lillian and Dr. Henry Rothberg a&nbsp;<a href="http://en.wikipedia.org/wiki/Chemical_engineer" title="Chemical engineer" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">chemical engineer</a>. Prior to Jonathan's birth, Lillian and Dr. Henry Rothberg founded&nbsp;<a href="http://en.wikipedia.org/wiki/Laticrete_International,_Inc." title="Laticrete International, Inc." style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Laticrete International, Inc.</a>&nbsp;a family-owned, global manufacturer of products for the installation of tile and stone. Jonathan's family established the foundation for his scientific career; early on, he was heavily influenced by his father's engineering background and problem solving abilities, as well as his mother's belief that he would &quot;do good science.&quot;<sup id="cite_ref-CT_Medal_of_Technology_1-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_note-CT_Medal_of_Technology-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap; background-position: initial initial; background-repeat: initial initial;">[1]</a></sup></p>
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<div>INSTITUTION AND LOCATION</div>
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<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Education_and_scientific_career">Education and scientific career</span><span class="mw-editsection mw-editsection-expanded" style="-webkit-user-select: none; font-size: small; margin-left: 1em; vertical-align: baseline; line-height: 1em; display: inline-block; white-space: nowrap; padding-right: 0.25em; unicode-bidi: -webkit-isolate; direction: ltr;"><span class="mw-editsection-bracket" style="margin-left: -0.25em; margin-right: 0.25em; color: rgb(85, 85, 85);">[</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;action=edit&amp;section=2&amp;editintro=Template:BLP_editintro" title="Edit section: Education and scientific career" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit source</a><span class="mw-editsection-divider" style="color: rgb(85, 85, 85);">&nbsp;|&nbsp;</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;veaction=edit&amp;section=2&amp;editintro=Template:BLP_editintro" title="Edit section: Education and scientific career" class="mw-editsection-visualeditor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit<span class="ve-tabmessage-appendix" style="font-size: 0.7em; vertical-align: top; line-height: 1.43em; padding-left: 0.5em; background-image: none !important; display: inline !important;">beta</span></a><span class="mw-editsection-bracket" style="margin-right: -0.25em; margin-left: 0.25em; color: rgb(85, 85, 85);">]</span></span></h2>
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<div>&nbsp;</div>
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<div>DEGREE</div>
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    <tbody>
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<div>&nbsp;</div>
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        <tr>
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<div>YEAR</div>
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            <th style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em; background-color: rgb(242, 242, 242); text-align: center;">INSTITUTION AND LOCATION</th>
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<div>&nbsp;</div>
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            <th style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em; background-color: rgb(242, 242, 242); text-align: center;">DEGREE</th>
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<div>FIELD OF STUDY</div>
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            <th style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em; background-color: rgb(242, 242, 242); text-align: center;">YEAR</th>
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<div>&nbsp;</div>
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            <th style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em; background-color: rgb(242, 242, 242); text-align: center;">FIELD OF STUDY</th>
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<div>Yale University, New Haven, CT</div>
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        </tr>
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<div>&nbsp;</div>
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        <tr>
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<div>Ph.D.</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">Yale University, New Haven, CT</td>
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<div>&nbsp;</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">Ph.D.</td>
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<div>1991</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">1991</td>
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<div>&nbsp;</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">Biology</td>
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<div>Biology</div>
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        </tr>
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<div>&nbsp;</div>
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        <tr>
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<div>Yale University, New Haven, CT</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">Yale University, New Haven, CT</td>
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<div>&nbsp;</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">M.Phil.</td>
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<div>M.Phil.</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">1988</td>
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<div>&nbsp;</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">Biology</td>
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<div>1988</div>
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        </tr>
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<div>&nbsp;</div>
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        <tr>
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<div>Biology</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">Yale University, New Haven, CT</td>
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<div>&nbsp;</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">M.S.</td>
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<div>Yale University, New Haven, CT</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">1987</td>
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<div>&nbsp;</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">Biology</td>
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<div>M.S.</div>
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        </tr>
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<div>&nbsp;</div>
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        <tr>
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<div>1987</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">Carnegie Mellon University, Pittsburgh, PA</td>
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<div>&nbsp;</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">B.S.</td>
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<div>Biology</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">1985</td>
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<div>&nbsp;</div>
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            <td style="border-style: solid; border-color: rgb(170, 170, 170); padding: 0.2em;">Chemical Engineering &ndash; option in Biomedical Engineering</td>
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<div>Carnegie Mellon University, Pittsburgh, PA</div>
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        </tr>
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<div>&nbsp;</div>
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    </tbody>
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<div>B.S.</div>
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</table>
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<div>&nbsp;</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Rothberg earned a&nbsp;<a href="http://en.wikipedia.org/wiki/Bachelor_of_Science" title="Bachelor of Science" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">B.S.</a>&nbsp;in&nbsp;<a href="http://en.wikipedia.org/wiki/Chemical_Engineering" title="Chemical Engineering" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Chemical Engineering</a>&nbsp;with an option in&nbsp;<a href="http://en.wikipedia.org/wiki/Biomedical_Engineering" title="Biomedical Engineering" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Biomedical Engineering</a>&nbsp;from&nbsp;<a href="http://en.wikipedia.org/wiki/Carnegie_Mellon_University" title="Carnegie Mellon University" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Carnegie Mellon University</a>,&nbsp;<a href="http://en.wikipedia.org/wiki/Pittsburgh" title="Pittsburgh" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Pittsburgh</a>, PA in 1985. After completing college at Carnegie Mellon, Jonathan went on to attend&nbsp;<a href="http://en.wikipedia.org/wiki/Yale_University" title="Yale University" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Yale University</a>&nbsp;and earn a&nbsp;<a href="http://en.wikipedia.org/wiki/Master_of_Science" title="Master of Science" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">M.S.</a>,&nbsp;<a href="http://en.wikipedia.org/wiki/Master_of_Philosophy" title="Master of Philosophy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">M.Phil.</a>, and&nbsp;<a href="http://en.wikipedia.org/wiki/Doctor_of_Philosophy" title="Doctor of Philosophy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Ph.D.</a>&nbsp;in biology. His thesis at Yale focused on decoding a&nbsp;<a href="http://en.wikipedia.org/wiki/Gene" title="Gene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">gene</a>&nbsp;called&nbsp;<a href="http://en.wikipedia.org/wiki/Slit_(gene)" title="Slit (gene)" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;"><i>slit</i></a>&nbsp;responsible for wiring the nervous system. Jonathan's thesis work resulted in publication of a cover article in the journal&nbsp;<i>Cell</i>&nbsp;in 1988. While a graduate student at Yale Jonathan founded CuraGen, one of the first genomics companies (<a rel="nofollow" class="external text" href="http://www.celldextherapeutics.com/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">CellDex Therapeutics</a>&nbsp;acquired CuraGen in fall of 2009).<sup id="cite_ref-CellDex_acquires_CuraGen_2-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_note-CellDex_acquires_CuraGen-2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap; background-position: initial initial; background-repeat: initial initial;">[2]</a></sup>&nbsp;At CuraGen, Jonathan and his team focused on how the proteins encoded in a genome function together, and published the first global proteomic maps of a eukaryotic cell and a metazoan organism (featured on the covers of Nature and Science) and developed drugs for the treatment of&nbsp;<a href="http://en.wikipedia.org/wiki/Skin_cancer" title="Skin cancer" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">metastatic skin</a>&nbsp;and&nbsp;<a href="http://en.wikipedia.org/wiki/Breast_cancer" title="Breast cancer" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">breast cancer</a>.</p>
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<div>1985</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Rothberg brought to market the first next-generation sequencer and has been a pioneering entrepreneur in the field of&nbsp;<a href="http://en.wikipedia.org/wiki/Single_molecule_fluorescent_sequencing" title="Single molecule fluorescent sequencing" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">massively parallel DNA sequencing</a><sup class="Template-Fact" style="line-height: 1em; white-space: nowrap;">[<i><a href="http://en.wikipedia.org/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;"><span title="This claim needs references to reliable sources. (November 2010)">citation needed</span></a></i>]</sup>. He founded&nbsp;<a href="http://en.wikipedia.org/wiki/454_Life_Sciences" title="454 Life Sciences" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">454 Life Sciences</a>&nbsp;Corporation, later acquired by&nbsp;<a href="http://en.wikipedia.org/wiki/Roche_Diagnostics" title="Roche Diagnostics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Roche Diagnostics</a>, and&nbsp;<a href="http://en.wikipedia.org/wiki/Ion_Torrent" title="Ion Torrent" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Ion Torrent</a>, companies that have commercialized technologies for DNA sequencing that have significantly reduced the cost of<a href="http://en.wikipedia.org/wiki/Sequencing" title="Sequencing" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">sequencing</a>&nbsp;a&nbsp;<a href="http://en.wikipedia.org/wiki/Genome" title="Genome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">genome</a>. His team at 454 Life Sciences and the&nbsp;<a href="http://en.wikipedia.org/wiki/Baylor_College_of_Medicine" title="Baylor College of Medicine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Baylor College of Medicine</a>&nbsp;Genome Center was the first to complete and make public the sequence of an individual&nbsp;<a href="http://en.wikipedia.org/wiki/Human_genome" title="Human genome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">human genome</a>&nbsp;(<a href="http://en.wikipedia.org/wiki/James_D._Watson" title="James D. Watson" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">James D. Watson</a><sup id="cite_ref-Bio-itworld_3-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_note-Bio-itworld-3" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap; background-position: initial initial; background-repeat: initial initial;">[3]</a></sup><sup id="cite_ref-NYT310507_4-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_note-NYT310507-4" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap; background-position: initial initial; background-repeat: initial initial;">[4]</a></sup>). Published in&nbsp;<i><a href="http://en.wikipedia.org/wiki/Nature" title="Nature" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Nature</a></i>&nbsp;magazine, that genome was made publicly on&nbsp;<a href="http://en.wikipedia.org/wiki/GenBank" title="GenBank" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">GenBank</a>&nbsp;and browsable via the efforts of&nbsp;<a href="http://en.wikipedia.org/wiki/Lincoln_Stein" title="Lincoln Stein" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Lincoln Stein</a>'s group&nbsp;<sup id="cite_ref-JWatsonSequ_5-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_note-JWatsonSequ-5" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap; background-position: initial initial; background-repeat: initial initial;">[5]</a></sup>&nbsp;contributing significantly to the new field of&nbsp;<a href="http://en.wikipedia.org/wiki/Personal_genomics" title="Personal genomics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">personal genomics</a>. Rothberg also initiated the&nbsp;<a href="http://en.wikipedia.org/wiki/Neanderthal_Genome_Project" title="Neanderthal Genome Project" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Neanderthal Genome Project</a>&nbsp;in collaboration with&nbsp;<a href="http://en.wikipedia.org/wiki/Svante_P%C3%A4%C3%A4bo" title="Svante P&auml;&auml;bo" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Svante P&auml;&auml;bo</a>'s group.<sup id="cite_ref-6" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_note-6" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap; background-position: initial initial; background-repeat: initial initial;">[6]</a></sup></p>
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<div>&nbsp;</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Under his tenure, 454 Life Sciences worked with collaborators to crack the mystery behind the disappearance of the honey bee, uncover a new virus killing transplant patients, and elucidate the extent of individual human variation&mdash;work recognized by Science magazine as the breakthrough of the year for 2007. The collective work of Dr. Rothberg's team, their collaborators and ultimately their customers, included projects as diverse as uncovering the complexity of life in the World's oceans and sequencing the extinct wooly mammoth.</p>
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<div>Chemical Engineering &ndash; &nbsp;option in Biomedical Engineering</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The New England Journal described Dr. Rothberg&rsquo;s sequencing innovation as &quot;The New Age of Molecular Diagnostics for Microbial Agents.&quot; Science magazine called it one of the top 10 breakthroughs for 2008. Dr. Rothberg has appeared on CNBC, CNN, and Bloomberg TV for his pioneering work in the field of genomic medicine, has been featured on the cover of Fortune magazine, and his scientific work has been featured on the covers of leading scientific journals including Cell, Science, and Nature. His contribution to sequencing, include both the first non-bacterial cloning systems (cloning by limited dilution), as well as the first massively parallel DNA sequencing method (sequencing by synthesis on a single substrate in parallel), concepts that have formed the basis for all subsequence next generation sequencing technologies.</p>
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<div>&nbsp;</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Rothberg is a member of the&nbsp;<a href="http://en.wikipedia.org/wiki/National_Academy_of_Engineering" title="National Academy of Engineering" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">National Academy of Engineering</a>, the Connecticut&nbsp;<a href="http://en.wikipedia.org/wiki/Academy_of_Medical_Sciences" title="Academy of Medical Sciences" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Academy of Medical Science and Engineering</a>, and is a life of trustees of&nbsp;<a href="http://en.wikipedia.org/wiki/Carnegie_Mellon_University" title="Carnegie Mellon University" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Carnegie Mellon University</a>.</p>
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<div>Rothberg earned a B.S. in Chemical Engineering with an option in Biomedical Engineering from Carnegie Mellon University, Pittsburgh, PA in 1985. &nbsp;After completing college at Carnegie Mellon, Jonathan went on to attend Yale University and earn a M.S., M.Phil., and Ph.D. in biology. &nbsp;His thesis at Yale focused on decoding a gene called slit responsible for wiring the nervous system. &nbsp;Jonathan's thesis work resulted in publication of a cover article in the journal Cell in 1988. &crarr;While a graduate student at Yale Jonathan founded CuraGen, one of the first genomics companies (CellDex Therapeutics acquired CuraGen in fall of 2009).[2] &nbsp;At CuraGen, Jonathan and his team focused on how the proteins encoded in a genome function together, and published the first global proteomic maps of a eukaryotic cell and a metazoan organism (featured on the covers of Nature and Science) and developed drugs for the treatment of metastatic skin and breast cancer.</div>
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<div>&nbsp;</div>
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<div>Rothberg brought to market the first next-generation sequencer and has been a pioneering entrepreneur in the field of massively parallel DNA sequencing[citation needed]. He founded 454 Life Sciences Corporation, later acquired by Roche Diagnostics, and Ion Torrent, companies that have commercialized technologies for DNA sequencing that have significantly reduced the cost of sequencing a genome. His team at 454 Life Sciences and the Baylor College of Medicine Genome Center was the first to complete and make public the sequence of an individual human genome (James D. Watson[3][4]). Published in Nature magazine, that genome was made publicly on GenBank and browsable via the efforts of Lincoln Stein's group [5] contributing significantly to the new field of personal genomics. &nbsp;Rothberg also initiated the Neanderthal Genome Project in collaboration with Svante P&auml;&auml;bo's group.[6]</div>
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<ul style="line-height: 19.200000762939453px; margin: 0.3em 0px 0px 1.6em; padding: 0px; list-style-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAUAAAANAQMAAABb8jbLAAAABlBMVEX///8AUow5QSOjAAAAAXRSTlMAQObYZgAAABNJREFUCB1jYEABBQw/wLCAgQEAGpIDyT0IVcsAAAAASUVORK5CYII=); font-family: sans-serif; font-size: 12.800000190734863px;">
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<div>&nbsp;</div>
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    <li style="margin-bottom: 0.1em;">2007&ndash;2013 Founder, CEO and Chairman of the Board, Ion Torrent, Inc., Guilford, CT</li>
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<div>Under his tenure, 454 Life Sciences worked with collaborators to crack the mystery behind the disappearance of the honey bee, uncover a new virus killing transplant patients, and elucidate the extent of individual human variation&mdash;work recognized by Science magazine as the breakthrough of the year for 2007. The collective work of Dr. Rothberg's team, their collaborators and ultimately their customers, included projects as diverse as uncovering the complexity of life in the World's oceans and sequencing the extinct wooly mammoth.</div>
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    <li style="margin-bottom: 0.1em;">2005&ndash;Present Board of Trustees, Carnegie Mellon University, Pittsburgh, PA</li>
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<div>&nbsp;</div>
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    <li style="margin-bottom: 0.1em;">2004&ndash;Present Co-Founder, Founding CEO, Chairman, RainDance Technologies, Inc., Guilford, CT</li>
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<div>The New England Journal described Dr. Rothberg&rsquo;s sequencing innovation as &quot;The New Age of Molecular Diagnostics for Microbial Agents.&quot; Science magazine called it one of the top 10 breakthroughs for 2008. Dr. Rothberg has appeared on CNBC, CNN, and Bloomberg TV for his pioneering work in the field of genomic medicine, has been featured on the cover of Fortune magazine, and his scientific work has been featured on the covers of leading scientific journals including Cell, Science, and Nature. His contribution to sequencing, include both the first non-bacterial cloning systems (cloning by limited dilution), as well as the first massively parallel DNA sequencing method (sequencing by synthesis on a single substrate in parallel), concepts that have formed the basis for all subsequence next generation sequencing technologies.</div>
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    <li style="margin-bottom: 0.1em;">2001&ndash;Present Founder, Chairman of the Board, Rothberg Institute for Childhood Diseases, Guilford, CT</li>
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<div>&nbsp;</div>
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    <li style="margin-bottom: 0.1em;">2000-2007 Founder, Founding CEO, Chairman of the Board, 454 Life Sciences, Branford, CT</li>
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<div>Rothberg is a member of the National Academy of Engineering, the Connecticut Academy of Medical Science and Engineering, and is a life of trustees of Carnegie Mellon University.</div>
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    <li style="margin-bottom: 0.1em;">1999-2007 Co-Founder, Chairman of the Board, Clarifi, Boca Raton</li>
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<div>&nbsp;</div>
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    <li style="margin-bottom: 0.1em;">1998&ndash;Present Board Member, Connecticut United for Research Excellence (CURE), New Haven, CT</li>
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<div>Positions and honors</div>
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    <li style="margin-bottom: 0.1em;">1993-2005 Founder, CEO, President, and Chairman of the Board, CuraGen Corporation, Branford, CT</li>
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<div>&nbsp;</div>
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    <li style="margin-bottom: 0.1em;">1991-1993 Post-Doctoral Fellow, Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, New Haven, CT</li>
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<div>Positions</div>
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</ul>
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<div>2007&ndash;2013 Founder, CEO and Chairman of the Board, Ion Torrent, Inc., Guilford, CT</div>
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<div>2005&ndash;Present &nbsp;Board of Trustees, Carnegie Mellon University, Pittsburgh, PA</div>
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<ul style="line-height: 19.200000762939453px; margin: 0.3em 0px 0px 1.6em; padding: 0px; list-style-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAUAAAANAQMAAABb8jbLAAAABlBMVEX///8AUow5QSOjAAAAAXRSTlMAQObYZgAAABNJREFUCB1jYEABBQw/wLCAgQEAGpIDyT0IVcsAAAAASUVORK5CYII=); font-family: sans-serif; font-size: 12.800000190734863px;">
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<div>2004&ndash;Present &nbsp;Co-Founder, Founding CEO, Chairman, RainDance Technologies, Inc., Guilford, CT</div>
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    <li style="margin-bottom: 0.1em;">2011 CBA Brilliant Achievement Award</li>
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<div>2001&ndash;Present &nbsp;Founder, Chairman of the Board, Rothberg Institute for Childhood Diseases, Guilford, CT</div>
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    <li style="margin-bottom: 0.1em;">2011 DGKL Biochemical Analysis Prize for development of massively parallel DNA sequencing</li>
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<div>2000-2007 &nbsp;Founder, Founding CEO, Chairman of the Board, 454 Life Sciences, Branford, CT</div>
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    <li style="margin-bottom: 0.1em;">2011 Doctor of Science Honoris Causa Mount Sinai School of Medicine</li>
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<div>1999-2007 &nbsp;Co-Founder, Chairman of the Board, Clarifi, Boca Raton</div>
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    <li style="margin-bottom: 0.1em;">2010 The World Economic Forum&rsquo;s Technology Pioneer (First person to be awarded three times)</li>
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<div>1998&ndash;Present &nbsp;Board Member, Connecticut United for Research Excellence (CURE), New Haven, CT</div>
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    <li style="margin-bottom: 0.1em;">2010 Connecticut Medal of Technology<sup id="cite_ref-7" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_note-7" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap; background-position: initial initial; background-repeat: initial initial;">[7]</a></sup></li>
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<div>1993-2005 &nbsp;Founder, CEO, President, and Chairman of the Board, CuraGen Corporation, Branford, CT</div>
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    <li style="margin-bottom: 0.1em;">2008 The World Economic Forum&rsquo;s Technology Pioneer</li>
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<div>1991-1993 &nbsp;Post-Doctoral Fellow, Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, New Haven, CT</div>
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    <li style="margin-bottom: 0.1em;">2007 The World Economic Forum&rsquo;s Technology Pioneer</li>
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<div>Honors and awards</div>
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    <li style="margin-bottom: 0.1em;">2006 R &amp; D 100 Awards for 454 Life Sciences</li>
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<div>2011 CBA Brilliant Achievement Award</div>
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    <li style="margin-bottom: 0.1em;">2005 Wall Street Journal 2005 Technology Innovation Awards, Gold Medal Winner</li>
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<div>2011 DGKL Biochemical Analysis Prize for development of massively parallel DNA &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; sequencing</div>
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    <li style="margin-bottom: 0.1em;">2005 Connecticut Academy of Science and Engineering</li>
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<div>2011 Doctor of Science Honoris Causa Mount Sinai School of Medicine</div>
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    <li style="margin-bottom: 0.1em;">2004 National Academy of Engineering</li>
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<div>2010 The World Economic Forum&rsquo;s Technology Pioneer (First person to be awarded three times)</div>
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    <li style="margin-bottom: 0.1em;">2000 The Irvington Institute&rsquo;s Corporate Leadership Award in Science</li>
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<div>2010 &nbsp;Connecticut Medal of Technology[7]</div>
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    <li style="margin-bottom: 0.1em;">1998 Ernst and Young Entrepreneur of the Year</li>
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<div>2008 The World Economic Forum&rsquo;s Technology Pioneer</div>
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    <li style="margin-bottom: 0.1em;">1991 John Spangler Nicholas Prize for the outstanding Doctoral candidate in Experimental Zoology</li>
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<div>2007 The World Economic Forum&rsquo;s Technology Pioneer</div>
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    <li style="margin-bottom: 0.1em;">1985-1989 National Research Service Award, National Institutes of Health</li>
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<div>2006 R &amp; D 100 Awards for 454 Life Sciences</div>
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</ul>
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<div>2005 Wall Street Journal 2005 Technology Innovation Awards, Gold Medal Winner</div>
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<div>2005 &nbsp;Connecticut Academy of Science and Engineering</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">2004-2008 Member, Young Presidents&rsquo; Organization&nbsp;<a href="http://en.wikipedia.org/wiki/National_Academy_of_Engineering" title="National Academy of Engineering" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">National Academy of Engineering</a>&nbsp;Connecticut Academy of Medical Science and Engineering&nbsp;<a href="http://en.wikipedia.org/wiki/Carnegie_Mellon_University" title="Carnegie Mellon University" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Carnegie Mellon University</a>&nbsp;Board of Trustees</p>
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<div>2004 &nbsp;National Academy of Engineering</div>
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<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Companies">Companies</span><span class="mw-editsection mw-editsection-expanded" style="-webkit-user-select: none; font-size: small; margin-left: 1em; vertical-align: baseline; line-height: 1em; display: inline-block; white-space: nowrap; padding-right: 0.25em; unicode-bidi: -webkit-isolate; direction: ltr;"><span class="mw-editsection-bracket" style="margin-left: -0.25em; margin-right: 0.25em; color: rgb(85, 85, 85);">[</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;action=edit&amp;section=7&amp;editintro=Template:BLP_editintro" title="Edit section: Companies" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit source</a><span class="mw-editsection-divider" style="color: rgb(85, 85, 85);">&nbsp;|&nbsp;</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;veaction=edit&amp;section=7&amp;editintro=Template:BLP_editintro" title="Edit section: Companies" class="mw-editsection-visualeditor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit<span class="ve-tabmessage-appendix" style="font-size: 0.7em; vertical-align: top; line-height: 1.43em; padding-left: 0.5em; background-image: none !important; display: inline !important;">beta</span></a><span class="mw-editsection-bracket" style="margin-right: -0.25em; margin-left: 0.25em; color: rgb(85, 85, 85);">]</span></span></h2>
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<div>2000 &nbsp;The Irvington Institute&rsquo;s Corporate Leadership Award in Science</div>
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<div>1998 &nbsp;Ernst and Young Entrepreneur of the Year</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In 1991, Rothberg founded New Haven-based CuraGen, one of the first companies to develop drugs based on genomics. While at CuraGen, he developed a series of new medicines, in over 14 human clinical trials, for the treatment of a wide range of&nbsp;<a href="http://en.wikipedia.org/wiki/Cancer" title="Cancer" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">cancers</a>. CuraGen however never released any drug to market.<sup id="cite_ref-8" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_note-8" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap; background-position: initial initial; background-repeat: initial initial;">[8]</a></sup></p>
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<div>1991 &nbsp;John Spangler Nicholas Prize for the outstanding Doctoral candidate in Experimental Zoology</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="454_Life_Sciences">454 Life Sciences</span><span class="mw-editsection mw-editsection-expanded" style="-webkit-user-select: none; font-size: small; font-weight: normal; margin-left: 1em; vertical-align: baseline; line-height: 1em; display: inline-block; white-space: nowrap; padding-right: 0.25em; unicode-bidi: -webkit-isolate; direction: ltr;"><span class="mw-editsection-bracket" style="margin-left: -0.25em; margin-right: 0.25em; color: rgb(85, 85, 85);">[</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;action=edit&amp;section=9&amp;editintro=Template:BLP_editintro" title="Edit section: 454 Life Sciences" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit source</a><span class="mw-editsection-divider" style="color: rgb(85, 85, 85);">&nbsp;|&nbsp;</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;veaction=edit&amp;section=9&amp;editintro=Template:BLP_editintro" title="Edit section: 454 Life Sciences" class="mw-editsection-visualeditor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit<span class="ve-tabmessage-appendix" style="font-size: 0.7em; vertical-align: top; line-height: 1.43em; padding-left: 0.5em; background-image: none !important; display: inline !important;">beta</span></a><span class="mw-editsection-bracket" style="margin-right: -0.25em; margin-left: 0.25em; color: rgb(85, 85, 85);">]</span></span></h3>
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<div>1985-1989 &nbsp;National Research Service Award, National Institutes of Health</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In 1999, Rothberg founded&nbsp;<a href="http://en.wikipedia.org/wiki/454_Life_Sciences" title="454 Life Sciences" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">454 Life Sciences</a>, based in&nbsp;<a href="http://en.wikipedia.org/wiki/Branford" title="Branford" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">Branford</a>&nbsp;(CT), which pioneered an entirely new way to sequence genomes.</p>
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<div>Professional memberships</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Ion_Torrent">Ion Torrent</span><span class="mw-editsection mw-editsection-expanded" style="-webkit-user-select: none; font-size: small; font-weight: normal; margin-left: 1em; vertical-align: baseline; line-height: 1em; display: inline-block; white-space: nowrap; padding-right: 0.25em; unicode-bidi: -webkit-isolate; direction: ltr;"><span class="mw-editsection-bracket" style="margin-left: -0.25em; margin-right: 0.25em; color: rgb(85, 85, 85);">[</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;action=edit&amp;section=10&amp;editintro=Template:BLP_editintro" title="Edit section: Ion Torrent" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit source</a><span class="mw-editsection-divider" style="color: rgb(85, 85, 85);">&nbsp;|&nbsp;</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;veaction=edit&amp;section=10&amp;editintro=Template:BLP_editintro" title="Edit section: Ion Torrent" class="mw-editsection-visualeditor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit<span class="ve-tabmessage-appendix" style="font-size: 0.7em; vertical-align: top; line-height: 1.43em; padding-left: 0.5em; background-image: none !important; display: inline !important;">beta</span></a><span class="mw-editsection-bracket" style="margin-right: -0.25em; margin-left: 0.25em; color: rgb(85, 85, 85);">]</span></span></h3>
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<div>2004-2008 &nbsp;Member, Young Presidents&rsquo; Organization&crarr;National Academy of Engineering&crarr;Connecticut Academy of Medical Science and Engineering&crarr;Carnegie Mellon University Board of Trustees</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Rothberg founded Ion Torrent in 2007, who developed&nbsp;<a href="http://en.wikipedia.org/wiki/Ion_semiconductor_sequencing" title="Ion semiconductor sequencing" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">ion semiconductor sequencing</a>&nbsp;which is utilized by their PGM DNA sequencer.<sup id="cite_ref-ion_torrent_9-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_note-ion_torrent-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap; background-position: initial initial; background-repeat: initial initial;">[9]</a></sup></p>
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<div>&nbsp;</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Rothberg_Center_for_Childhood_diseases">Rothberg Center for Childhood diseases</span><span class="mw-editsection mw-editsection-expanded" style="-webkit-user-select: none; font-size: small; font-weight: normal; margin-left: 1em; vertical-align: baseline; line-height: 1em; display: inline-block; white-space: nowrap; padding-right: 0.25em; unicode-bidi: -webkit-isolate; direction: ltr;"><span class="mw-editsection-bracket" style="margin-left: -0.25em; margin-right: 0.25em; color: rgb(85, 85, 85);">[</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;action=edit&amp;section=11&amp;editintro=Template:BLP_editintro" title="Edit section: Rothberg Center for Childhood diseases" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit source</a><span class="mw-editsection-divider" style="color: rgb(85, 85, 85);">&nbsp;|&nbsp;</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;veaction=edit&amp;section=11&amp;editintro=Template:BLP_editintro" title="Edit section: Rothberg Center for Childhood diseases" class="mw-editsection-visualeditor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit<span class="ve-tabmessage-appendix" style="font-size: 0.7em; vertical-align: top; line-height: 1.43em; padding-left: 0.5em; background-image: none !important; display: inline !important;">beta</span></a><span class="mw-editsection-bracket" style="margin-right: -0.25em; margin-left: 0.25em; color: rgb(85, 85, 85);">]</span></span></h3>
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<div>Companies</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Rothberg is a founder of the Rothberg Center for Childhood diseases.</p>
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<div>&nbsp;</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="RainDance_Technologies">RainDance Technologies</span><span class="mw-editsection mw-editsection-expanded" style="-webkit-user-select: none; font-size: small; font-weight: normal; margin-left: 1em; vertical-align: baseline; line-height: 1em; display: inline-block; white-space: nowrap; padding-right: 0.25em; unicode-bidi: -webkit-isolate; direction: ltr;"><span class="mw-editsection-bracket" style="margin-left: -0.25em; margin-right: 0.25em; color: rgb(85, 85, 85);">[</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;action=edit&amp;section=12&amp;editintro=Template:BLP_editintro" title="Edit section: RainDance Technologies" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit source</a><span class="mw-editsection-divider" style="color: rgb(85, 85, 85);">&nbsp;|&nbsp;</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;veaction=edit&amp;section=12&amp;editintro=Template:BLP_editintro" title="Edit section: RainDance Technologies" class="mw-editsection-visualeditor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit<span class="ve-tabmessage-appendix" style="font-size: 0.7em; vertical-align: top; line-height: 1.43em; padding-left: 0.5em; background-image: none !important; display: inline !important;">beta</span></a><span class="mw-editsection-bracket" style="margin-right: -0.25em; margin-left: 0.25em; color: rgb(85, 85, 85);">]</span></span></h3>
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<div>CuraGen</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Founded first company to use droplet based microfluidics</p>
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<div>In 1991, Rothberg founded New Haven-based CuraGen, one of the first companies to develop drugs based on genomics. While at CuraGen, he developed a series of new medicines, in over 14 human clinical trials, for the treatment of a wide range of cancers. CuraGen however never released any drug to market.[8]</div>
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<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Selected_Publications">Selected Publications</span><span class="mw-editsection mw-editsection-expanded" style="-webkit-user-select: none; font-size: small; margin-left: 1em; vertical-align: baseline; line-height: 1em; display: inline-block; white-space: nowrap; padding-right: 0.25em; unicode-bidi: -webkit-isolate; direction: ltr;"><span class="mw-editsection-bracket" style="margin-left: -0.25em; margin-right: 0.25em; color: rgb(85, 85, 85);">[</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;action=edit&amp;section=13&amp;editintro=Template:BLP_editintro" title="Edit section: Selected Publications" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit source</a><span class="mw-editsection-divider" style="color: rgb(85, 85, 85);">&nbsp;|&nbsp;</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;veaction=edit&amp;section=13&amp;editintro=Template:BLP_editintro" title="Edit section: Selected Publications" class="mw-editsection-visualeditor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit<span class="ve-tabmessage-appendix" style="font-size: 0.7em; vertical-align: top; line-height: 1.43em; padding-left: 0.5em; background-image: none !important; display: inline !important;">beta</span></a><span class="mw-editsection-bracket" style="margin-right: -0.25em; margin-left: 0.25em; color: rgb(85, 85, 85);">]</span></span></h2>
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<div>&nbsp;</div>
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<ol style="line-height: 19.200000762939453px; margin: 0.3em 0px 0px 3.2em; padding: 0px; list-style-image: none; font-family: sans-serif; font-size: 12.800000190734863px;">
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<div>454 Life Sciences</div>
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    <li style="margin-bottom: 0.1em;">Rothberg, J.M. et al., An integrated semiconductor device enabling non-optical genome sequencing. Nature 475, July 2011. 348-352.</li>
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<div>In 1999, Rothberg founded 454 Life Sciences, based in Branford (CT), which pioneered an entirely new way to sequence genomes.</div>
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    <li style="margin-bottom: 0.1em;">Alexander Mellmann., Dag Harmsen., Craig A. Cummings., Emily B. Zentz, Shana R. Leopold, Alain Rico, Karola Prior, Rafael Szczepanowski, Yongmei Ji, Wenlan Zhang, Stephen F. McLaughlin, John K. Henkhaus, Benjamin Leopold, Martina Bielaszewska, Rita Prager, Pius M. Brzoska, Richard L. Moore, Simone Guenther, Jonathan M. Rothberg, Helge Karch. Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology. PLOS one, Volume 6, Issue 7, July 2011.</li>
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<div>&nbsp;</div>
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    <li style="margin-bottom: 0.1em;">E. Brouzes, M. Medkova, N Savenelli, D. Marran, M. Twardowski, J. B. Hutchinon, J. J. M. Rothberg, D.R. Link,&nbsp;<a href="http://en.wikipedia.org/wiki/N._Perrimon" title="N. Perrimon" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">N. Perrimon</a>, M. L. Samuels. Droplet microfluidic technology for single-cell high thoughput screening. PNAS, July 2009, Vol. 106, no. 106</li>
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<div>Ion Torrent</div>
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    <li style="margin-bottom: 0.1em;">Birgitte B. Simen, Jan Fredrik Simons, Katherine Huppler Hullsiek,,Richard M. Novak, Rodger D. MacArthur, John D. Baxter, Chunli Huang,,Christine Lubeski, Gregory S. Turenchalk, Michael S. Braverman, Brian Desany, Jonathan M. Rothberg, Michael Egholm, Michael J. Kozal. Low-Abundance Drug-Resistant Viral Variants in Chronically HIV-Infected, Antiretroviral Treatment-Na&iuml;ve Patients Significantly Impact Treatment Outcomes. The Journal of Infectious Diseases. 2009; 199:693-701.</li>
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<div>Rothberg founded Ion Torrent in 2007, who developed ion semiconductor sequencing which is utilized by their PGM DNA sequencer.[9]</div>
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    <li style="margin-bottom: 0.1em;">Richard E Green, Anna-Sapfo Malaspinas, Johannes Krause, Adrian W Briggs, Philip L F Johnson, Caroline Uhler, Matthias Meyer, Jeffrey M Good, Tomislav Maricic, Udo Stenzel, Kay Pr&uuml;fer, Michael Siebauer, Hern&aacute;n A Burbano, Michael Ronan, Jonathan M Rothberg, Michael Egholm, Pavao Rudan, Dejana Brajković, Zeljko Kućan, Ivan Gusić, M&aring;rten Wikstr&ouml;m, Liisa Laakkonen, Janet Kelso, Montgomery Slatkin, Svante P&auml;&auml;bo. A complete neandertal mitochondrial genome sequence determined by high-throughput sequencing. [Cover Paper] Cell. 2008 Aug 8;134 (3):416-26</li>
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<div>&nbsp;</div>
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    <li style="margin-bottom: 0.1em;">David A Wheeler, Maithreyan Srinivasan, Michael Egholm, Yufeng Shen, Lei Chen, Amy McGuire, Wen He, Yi-Ju Chen, Vinod Makhijani, G Thomas Roth, Xavier Gomes, Karrie Tartaro, Faheem Niazi, Cynthia L Turcotte, Gerard P Irzyk, James R Lupski, Craig Chinault, Xing-Zhi Song, Yue Liu, Ye Yuan, Lynne Nazareth, Xiang Qin, Donna M Muzny, Marcel Margulies, George M Weinstock, Richard A Gibbs, Jonathan M Rothberg. The complete genome of an individual by massively parallel DNA sequencing. Nature 2008 Apr 17;452 (7189):872-6</li>
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<div>Rothberg Center for Childhood diseases</div>
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    <li style="margin-bottom: 0.1em;">John H. Leamon, Michael S. Braverman and Jonathan M. Rothberg. High-Throughput, Massively Parallel DNA Sequencing Technology for the Era of Personalized Medicine? Gene Therapy and Regulation, 2007, vol. 2, no. 1, 15-31.</li>
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<div>Rothberg is a founder of the Rothberg Center for Childhood diseases.</div>
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    <li style="margin-bottom: 0.1em;">John H. Leamon and Jonathan M. Rothberg. Cramming More Sequencing Reactions onto Microreactor Chips. Chemical Reviews, 2007 Aug; 107(8):3367-76.</li>
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<div>&nbsp;</div>
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    <li style="margin-bottom: 0.1em;">Green, R.E., Krause, J., Ptak, S.E., Briggs, A.W., Ronan, M., Simons, J.F., Egholm, M., Rothberg, J., Paunovic, M., and P&auml;&auml;bo, S.: Analysis of one million base pairs of Neandertal DNA. [Cover Paper] Nature 444, 330-336.16 November 2006</li>
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<div>RainDance Technologies</div>
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    <li style="margin-bottom: 0.1em;">Robert Pinard, Alex de Winter, Gary J Sarkis, Mark B Gerstein, Karrie R Tartaro, Ramona N Plant, Michael Egholm, Jonathan M Rothberg, and John H Leamon. Assessment of whole genome amplification-induced bias through high-throughput, massively parallel whole genome sequencing. BMC Genomics. 2006; 7: 216. Published online 2006 August 23.</li>
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<div>Founded first company to use droplet based microfluidics</div>
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    <li style="margin-bottom: 0.1em;">Stiller, M., Green, R.E., Ronan, M., Simons, J.F., Du, L., He, W., Egholm, M., Rothberg, J., Keates, S.G., Ovodov, N.D., Antipina, E.E., Baryshnikov, G.F., Kuzmin, Y.V., Vasilevski, A.A., Wuenschell, G.E., Termini, J., Hofreiter, M., Jaenicke-Despr&eacute;s, V., and P&auml;&auml;bo, S.: Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA. PNAS, September 12, 2006, vol. 103, no. 37, 13578-13584.</li>
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<div>&nbsp;</div>
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    <li style="margin-bottom: 0.1em;">Thomas RK, Nickerson E, Simons JF, Janne PA, Tengs T, Yuza Y, Garraway LA, Laframboise T, Lee JC, Shah K, O'neill K, Sasaki H, Lindeman N, Wong KK, Borras AM, Gutmann EJ, Dragnev KH, Debiasi R, Chen TH, Glatt KA, Greulich H, Desany B, Lubeski CK, Brockman W, Alvarez P, Hutchison SK, Leamon JH, Ronan MT, Turenchalk GS, Egholm M, Sellers WR, Rothberg JM, Meyerson M. Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing. Nat Med. 2006 Jul;12(7):852-855.</li>
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<div>Selected Publications</div>
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    <li style="margin-bottom: 0.1em;">Leamon JH, Link DR, Egholm M, Rothberg JM. Overview: methods and applications for droplet compartmentalization of biology. Nat Methods. 2006 Jul;3(7):541-3.</li>
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<div>&nbsp;</div>
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    <li style="margin-bottom: 0.1em;">Thomas RK, Greulich H, Yuza Y, Lee JC, Tengs T, Feng W, Chen TH, Nickerson E, Simons J, Egholm M, Rothberg JM, Sellers WR, and Meyerson ML. Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors. Cold Spring Harb Symp Quant Biol. 2005; 70: 73-81.</li>
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<div>Rothberg, J.M. et al., An integrated semiconductor device enabling non-optical genome sequencing. Nature 475, July 2011. 348-352.</div>
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    <li style="margin-bottom: 0.1em;">Margulies M, Egholm M, Altman WE, Attiya S, Bader JS, Bemben LA., Berka J, Braverman MS, Chen YJ, Chen Z, Dewell SB, de Winter A, Drake J, Du L, Fierro JM, Forte R, Gomes XV, Godwin BC, He W, Helgesen S, Ho CH, Hutchison SK, Irzyk GP, Jando SC, Alenquer MLI, Jarvie TP, Jirage KB, Kim JB, Knight JR, Lanza JR, Leamon JH, Lee WL, Lefkowitz SM, Lei M, Li J, Lohman KL, Lu H, Makhijani VB, McDade KE, McKenna MP, Myers EW, Nickerson E, Nobile JR, Plant R, Puc BP, Reifler M Ronan MT, Roth GT, Sarkis GJ, Simons JF, Simpson JW, Srinivasan M, Tartaro KR, Tomasz A, Vogt KA, Volkmer GA, Wang SH, Wang Y, Weiner MP, Willoughby DA, Yu P, Begley RF, Rothberg JM. Genome sequencing in microfabricated high-density picolitre reactors. Nature 2005; 441.7089.</li>
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<div>Alexander Mellmann., Dag Harmsen., Craig A. Cummings., Emily B. Zentz, Shana R. Leopold, Alain Rico, Karola Prior, Rafael Szczepanowski, Yongmei Ji, Wenlan Zhang, Stephen F. McLaughlin, John K. Henkhaus, Benjamin Leopold, Martina Bielaszewska, Rita Prager, Pius M. Brzoska, Richard L. Moore, Simone Guenther, Jonathan M. Rothberg, Helge Karch. Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology. PLOS one, Volume 6, Issue 7, July 2011.</div>
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    <li style="margin-bottom: 0.1em;">Gunther EC, Stone DJ, Rothberg JM, and Gerwien RW. A quantitative genomic expression analysis platform for multiplexed&nbsp;<i>in vitro</i>&nbsp;prediction of drug action. The Pharmacogenomics Journal 5, 2005, 126-134.</li>
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<div>E. Brouzes, M. Medkova, N Savenelli, D. Marran, M. Twardowski, J. B. Hutchinon, J. J. M. Rothberg, D.R. Link, N. Perrimon, M. L. Samuels. &nbsp;Droplet microfluidic technology for single-cell high thoughput screening. PNAS, July &nbsp;2009, Vol. 106, no. 106</div>
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    <li style="margin-bottom: 0.1em;">Gould Rothberg BE, Pena CEA, Rothberg JM. A systems biology approach to target identification and validation for human chronic disease drug discovery. Division of Chronic Disease Epidemiology, Yale University School of Public Health. Modern Biopharmaceuticals 2005; 1 99-125.</li>
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<div>Birgitte B. Simen, Jan Fredrik Simons, Katherine Huppler Hullsiek,,Richard M. Novak, Rodger D. MacArthur, John D. Baxter, Chunli Huang,,Christine Lubeski, Gregory S. Turenchalk, Michael S. Braverman, Brian Desany, Jonathan M. Rothberg, Michael Egholm, Michael J. Kozal. Low-Abundance Drug-Resistant Viral Variants in Chronically HIV-Infected, Antiretroviral Treatment-Na&iuml;ve Patients Significantly Impact Treatment Outcomes. The Journal of Infectious Diseases. 2009; 199:693-701.</div>
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    <li style="margin-bottom: 0.1em;">Bader JS, Chaudhuri A. Rothberg JM, and Chant J. Gaining confidence in high-throughput protein interaction networks. Nature Biotechnology 2003; 10.1038.</li>
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<div>Richard E Green, Anna-Sapfo Malaspinas, Johannes Krause, Adrian W Briggs, Philip L F Johnson, Caroline Uhler, Matthias Meyer, Jeffrey M Good, Tomislav Maricic, Udo Stenzel, Kay Pr&uuml;fer, Michael Siebauer, Hern&aacute;n A Burbano, Michael Ronan, Jonathan M Rothberg, Michael Egholm, Pavao Rudan, Dejana Brajković, Zeljko Kućan, Ivan Gusić, M&aring;rten Wikstr&ouml;m, Liisa Laakkonen, Janet Kelso, Montgomery Slatkin, Svante P&auml;&auml;bo. A complete neandertal mitochondrial genome sequence determined by high-throughput sequencing. &nbsp;[Cover Paper] Cell. 2008 Aug 8;134 (3):416-26</div>
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    <li style="margin-bottom: 0.1em;">Leamon JH, Lee WL, Tartaro KR Lanza JR, Sarkis GJ, deWinter AD, Berka J, Weiner M, Rothberg JM, Lohman KL. A massively parallel PicoTitlerPlate based platform for discrete picoliter-scale polymerase chain reactions. Electrophoresis 24(21). November 2003:3769-77, Erratum in Eletrophoresis.25 1176 April 204: 7-8.</li>
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<div>David A Wheeler, Maithreyan Srinivasan, Michael Egholm, Yufeng Shen, Lei Chen, Amy McGuire, Wen He, Yi-Ju Chen, Vinod Makhijani, G Thomas Roth, Xavier Gomes, Karrie Tartaro, Faheem Niazi, Cynthia L Turcotte, Gerard P Irzyk, James R Lupski, Craig Chinault, Xing-Zhi Song, Yue Liu, Ye Yuan, Lynne Nazareth, Xiang Qin, Donna M Muzny, Marcel Margulies, George M Weinstock, Richard A Gibbs, Jonathan M Rothberg. &nbsp;The complete genome of an individual by massively parallel DNA sequencing. Nature 2008 Apr 17;452 (7189):872-6</div>
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    <li style="margin-bottom: 0.1em;">Giot L, Bader JS, Brouwer C, Chaudhuri A, Kuang B, Li Y, Hoa YL, Oi CE, Godwin G, Vitols E, Vijayadamodar G, Pochart P, Machineni H, Welsh, M, Kong Y, Zerhusen B, Malcolm R, Varrone Z, Collis A, Minto M, Burgess S, McDaniel L, Stimpson E, Springs F, Williams J, Neurath K, Ioime N, Agee M, Voss E, Furkat K, Renzulli R, Aanensen N, Carrolla S, Bickelhaupt E, Lazovatsky Y, DaSilva A, Zhong J, Stanyon CA, Finley Jr RL, White KP, Braverman M, Jarvie T, Gold S, Leach M, Knight J, Shimkets RA, McKenna MP, Chant J, and Rothberg JM. Protein Interaction Map of Drosophila melanogaster. [Cover paper] Science November 2, 2003; 10.1126.</li>
+
<div>John H. Leamon, Michael S. Braverman and Jonathan M. Rothberg. High-Throughput, Massively Parallel DNA Sequencing Technology for the Era of Personalized Medicine? Gene Therapy and Regulation, 2007, vol. 2, no. 1, 15-31.</div>
-
    <li style="margin-bottom: 0.1em;">Bader JS, Deem MW, Hammond RW, Henck SA, Simpson JW, Rothberg JM. A Brownian-ratchet DNA pump with applications to single-nucleotide polymorphism genotyping. Applied Physics A: Materials Science &amp; Processing. 2000; Vol. 75, 275-278.</li>
+
<div>John H. Leamon and Jonathan M. Rothberg. Cramming More Sequencing Reactions onto Microreactor Chips. Chemical Reviews, 2007 Aug; 107(8):3367-76.</div>
-
    <li style="margin-bottom: 0.1em;">Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K; Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. Molecular Medicine 2002; Vol. 8, 56-64.</li>
+
<div>Green, R.E., Krause, J., Ptak, S.E., Briggs, A.W., Ronan, M., Simons, J.F., Egholm, M., Rothberg, J., Paunovic, M., and P&auml;&auml;bo, S.: Analysis of one million base pairs of Neandertal DNA. [Cover Paper] Nature 444, 330-336.16 November 2006</div>
-
    <li style="margin-bottom: 0.1em;">LaRochelle WJ, Jeffers M, McDonald WF, Chillakuru RA, N Lokker NA, Sullivan C, Boldog FL, Yang, M, Vernet C, Burgess CE, Fernandes E, Deegler LL, Rittman B, Shimkets J, Shimkets RA, Rothberg JM, and Lichenstein HS. PDGF-D, a new protease-activated growth factor. Nature Cell Biology May 1, 2001; Vol. 3. 517-521.</li>
+
<div>Robert Pinard, Alex de Winter, Gary J Sarkis, Mark B Gerstein, Karrie R Tartaro, Ramona N Plant, Michael Egholm, Jonathan M Rothberg, and John H Leamon. Assessment of whole genome amplification-induced bias through high-throughput, massively parallel whole genome sequencing. BMC Genomics. 2006; 7: 216. Published online 2006 August 23.</div>
-
    <li style="margin-bottom: 0.1em;">Herrmann J, Rastelli L, Brugess CE, Fernandes EE, Rothberg BEG, Rothberg JM, and Shimkets RA. Implications of Oncogenomics for Cancer Research and Clinical Oncology. The Cancer Journal. January/February 2001; Volume 7 Number 1.</li>
+
<div>Stiller, M., Green, R.E., Ronan, M., Simons, J.F., Du, L., He, W., Egholm, M., Rothberg, J., Keates, S.G., Ovodov, N.D., Antipina, E.E., Baryshnikov, G.F., Kuzmin, Y.V., Vasilevski, A.A., Wuenschell, G.E., Termini, J., Hofreiter, M., Jaenicke-Despr&eacute;s, V., and P&auml;&auml;bo, S.: Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA. PNAS, September 12, 2006, vol. 103, no. 37, 13578-13584.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg BEG, Sundseth SS, DiPippo VA, Brown PJ, Winegar DA, Gottshalk WK, Shenoy SG, and Rothberg JM. The characterization of PPAR&alpha; ligand drug action in an&nbsp;<i>in vivo</i>&nbsp;model by comprehensive differential gene expression profiling. [Cover paper] Functional and Integrative Genomics. October 2000.</li>
+
<div>Thomas RK, Nickerson E, Simons JF, Janne PA, Tengs T, Yuza Y, Garraway LA, Laframboise T, Lee JC, Shah K, O'neill K, Sasaki H, Lindeman N, Wong KK, Borras AM, Gutmann EJ, Dragnev KH, Debiasi R, Chen TH, Glatt KA, Greulich H, Desany B, Lubeski CK, Brockman W, Alvarez P, Hutchison SK, Leamon JH, Ronan MT, Turenchalk GS, Egholm M, Sellers WR, Rothberg JM, Meyerson M. &nbsp;Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing. Nat Med. 2006 Jul;12(7):852-855.</div>
-
    <li style="margin-bottom: 0.1em;">Uetz P, Giot L, Cagney G, Mansfield TA, Judson RS, Knight JR, Lockshon D, Narayan V, Sriivasan M, Pochart P, Qureshi-Emili A, Li Y, Godwin B, Conver D, Kalbfleisch T, Vijayadamodar G, Yang M, Johnston M, Fields S, and Rothberg JM. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. [Cover paper] Nature Feb 10, 2000; Vol. 403, 623-627.</li>
+
<div>Leamon JH, Link DR, Egholm M, Rothberg JM. Overview: methods and applications for droplet compartmentalization of biology. Nat Methods. 2006 Jul;3(7):541-3.</div>
-
    <li style="margin-bottom: 0.1em;">Simpson JW, Ruiz-Martinez MC, Mulhern GT, Berka J, Latimer DR, Ball JA, Rothberg JM, Went GT. A transmission imaging spectrograph and microfabricated channel system for DNA analysis. Electrophoresis 2000; Vol. 21, 135-149.</li>
+
<div>Thomas RK, Greulich H, Yuza Y, Lee JC, Tengs T, Feng W, Chen TH, Nickerson E, Simons J, Egholm M, Rothberg JM, Sellers WR, and Meyerson ML. Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors. Cold Spring Harb Symp Quant Biol. 2005; 70: 73-81.</div>
-
    <li style="margin-bottom: 0.1em;">Hammond RW, Bader JS, Henck SA, Deem MW, McDermott GA, Bustillo JM, Rothberg, JM. Differential transport of DNA by a rectified Brownian motion device. Electrophoresis 2000; Vol. 21, 74-80.</li>
+
<div>Margulies M, Egholm M, Altman WE, Attiya S, Bader JS, Bemben LA., Berka J, Braverman MS, Chen YJ, Chen Z, Dewell SB, de Winter A, Drake J, Du L, Fierro JM, Forte R, Gomes XV, Godwin BC, He W, Helgesen S, Ho CH, Hutchison SK, Irzyk GP, Jando SC, Alenquer MLI, Jarvie TP, Jirage KB, Kim JB, Knight JR, Lanza JR, Leamon JH, Lee WL, Lefkowitz SM, Lei M, Li J, Lohman KL, Lu H, Makhijani VB, McDade KE, McKenna MP, Myers EW, Nickerson E, Nobile JR, Plant R, Puc BP, Reifler M Ronan MT, Roth GT, Sarkis GJ, Simons JF, Simpson JW, Srinivasan M, Tartaro KR, Tomasz A, Vogt KA, Volkmer GA, Wang SH, Wang Y, Weiner MP, Willoughby DA, Yu P, Begley RF, Rothberg JM. &nbsp;Genome sequencing in microfabricated high-density picolitre reactors. &nbsp; &nbsp;Nature 2005; 441.7089.</div>
-
    <li style="margin-bottom: 0.1em;">Bader J, Hammond R W, Henck SA, Deem MW, McDermott GA, Bustillo JM, Simpson JW, Mulhern GT, and Rothberg JM. DNA transport by a micromachined Brownian ratchet device. PNAS USA November 9, 1999; Vol. 96 No. 23. 13165-9.</li>
+
<div>Gunther EC, Stone DJ, Rothberg JM, and Gerwien RW. A quantitative genomic expression analysis platform for multiplexed in vitro prediction of drug action. The Pharmacogenomics Journal 5, 2005, 126-134.</div>
-
    <li style="margin-bottom: 0.1em;">Shimkets R A, Lowe DG, Tsu-Ning Tai J, Sehl P, Jin H, Yang R, Predki P, Rothberg BEG, Murtha MT, Roth ME, Shenoy SG, McKenna MP, Hillan K, Went GT, and Rothberg JM. Gene expression analysis by transcript profiling coupled to a gene database query [GeneCalling]. Nature Biotechnology August 1999; Vol. 17, 798-803.</li>
+
<div>Gould Rothberg BE, Pena CEA, Rothberg JM. &nbsp; &nbsp;A systems biology approach to target identification and validation for human chronic disease drug discovery. Division of Chronic Disease Epidemiology, Yale University School of Public Health. Modern Biopharmaceuticals 2005; 1 99-125.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, and Artavanis-Tsakonas S. Modularity of the Slit Protein. J. Mol. Biol. 1992; 227, 367-370.</li>
+
<div>Bader JS, Chaudhuri A. Rothberg JM, and Chant J. Gaining confidence in high-throughput protein interaction networks. Nature Biotechnology 2003; 10.1038.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM. Gene Patents. Nature 1992; 356, 738.</li>
+
<div>Leamon JH, Lee WL, Tartaro KR Lanza JR, Sarkis GJ, deWinter AD, Berka J, Weiner M, Rothberg JM, Lohman KL. A massively parallel PicoTitlerPlate based platform for discrete picoliter-scale polymerase chain reactions. Electrophoresis 24(21). November 2003:3769-77, Erratum in Eletrophoresis.25 1176 April 204: 7-8.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM Ph.D. slit: an Extracellular Protein Necessary for the Development of Midline Glia and Axon Pathways of the Central Nervous System contains both EGF and Flank-LRR-Flank Domains. Thesis, Yale University, 1991.</li>
+
<div>Giot L, Bader JS, Brouwer C, Chaudhuri A, Kuang B, Li Y, Hoa YL, Oi CE, Godwin G, Vitols E, Vijayadamodar G, Pochart P, Machineni H, Welsh, M, Kong Y, Zerhusen B, Malcolm R, Varrone Z, Collis A, Minto M, Burgess S, McDaniel L, Stimpson E, Springs F, Williams J, Neurath K, Ioime N, Agee M, Voss E, Furkat K, Renzulli R, Aanensen N, Carrolla S, Bickelhaupt E, Lazovatsky Y, DaSilva A, Zhong J, Stanyon CA, Finley Jr RL, White KP, Braverman M, Jarvie T, Gold S, Leach M, Knight J, Shimkets RA, McKenna MP, Chant J, and Rothberg JM. Protein Interaction Map of Drosophila melanogaster. [Cover paper] Science November 2, 2003; 10.1126.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Jacobs J R, Goodman CS and Artavanis-Tsakonas S. slit: An Extracellular Protein Necessary for Development of Midline Glia and Commissural Axon Pathways Contains both EGF and LRR Domains. Genes &amp; Development 1990; 4, 2169-2187.</li>
+
<div>Bader JS, Deem MW, Hammond RW, Henck SA, Simpson JW, Rothberg JM. A Brownian-ratchet DNA pump with applications to single-nucleotide polymorphism genotyping. Applied Physics A: Materials Science &amp; Processing. 2000; Vol. 75, 275-278.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Hartley DA, Walther Z, and Artavanis-Tsakonas S. slit: An EGF-Homologous Locus of D. melanogaster Involved in the Development of the Embryonic Central Nervous System. [Cover paper] Cell 1988; 55, 1047-1059.</li>
+
<div>Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K; Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF. &nbsp; &nbsp;The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. &nbsp;Molecular Medicine 2002; Vol. 8, 56-64.</div>
-
</ol>
+
<div>LaRochelle WJ, Jeffers M, McDonald WF, Chillakuru RA, N Lokker NA, Sullivan C, Boldog FL, Yang, M, Vernet C, Burgess CE, Fernandes E, Deegler LL, Rittman B, Shimkets &nbsp;J, Shimkets RA, Rothberg JM, and Lichenstein HS. PDGF-D, a new protease-activated growth factor. Nature Cell Biology May 1, 2001; Vol. 3. 517-521.</div>
-
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Issued_U.S._Patents">Issued U.S. Patents</span><span class="mw-editsection mw-editsection-expanded" style="-webkit-user-select: none; font-size: small; margin-left: 1em; vertical-align: baseline; line-height: 1em; display: inline-block; white-space: nowrap; padding-right: 0.25em; unicode-bidi: -webkit-isolate; direction: ltr;"><span class="mw-editsection-bracket" style="margin-left: -0.25em; margin-right: 0.25em; color: rgb(85, 85, 85);">[</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;action=edit&amp;section=14&amp;editintro=Template:BLP_editintro" title="Edit section: Issued U.S. Patents" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit source</a><span class="mw-editsection-divider" style="color: rgb(85, 85, 85);">&nbsp;|&nbsp;</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;veaction=edit&amp;section=14&amp;editintro=Template:BLP_editintro" title="Edit section: Issued U.S. Patents" class="mw-editsection-visualeditor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit<span class="ve-tabmessage-appendix" style="font-size: 0.7em; vertical-align: top; line-height: 1.43em; padding-left: 0.5em; background-image: none !important; display: inline !important;">beta</span></a><span class="mw-editsection-bracket" style="margin-right: -0.25em; margin-left: 0.25em; color: rgb(85, 85, 85);">]</span></span></h2>
+
<div>Herrmann J, Rastelli L, Brugess CE, Fernandes EE, Rothberg BEG, Rothberg JM, and Shimkets RA. Implications of Oncogenomics for Cancer Research and Clinical Oncology. The Cancer Journal. January/February 2001; Volume 7 Number 1.</div>
-
<ol style="line-height: 19.200000762939453px; margin: 0.3em 0px 0px 3.2em; padding: 0px; list-style-image: none; font-family: sans-serif; font-size: 12.800000190734863px;">
+
<div>Rothberg BEG, Sundseth SS, DiPippo VA, Brown PJ, Winegar DA, Gottshalk WK, Shenoy SG, and Rothberg JM. The characterization of PPAR&alpha; ligand drug action in an in vivo model by comprehensive differential gene expression profiling. [Cover paper] Functional and Integrative Genomics. October 2000.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg J, Wolfgang H, Johnson K, Bustillo J, Methods and apparatus for measuring analytes using large scale FET arrays. USP# 7,948.015</li>
+
<div>Uetz P, Giot L, Cagney G, Mansfield TA, Judson RS, Knight JR, Lockshon D, Narayan V, Sriivasan M, Pochart P, Qureshi-Emili A, Li Y, Godwin B, Conver D, Kalbfleisch T, Vijayadamodar G, Yang M, Johnston M, Fields S, and Rothberg JM. &nbsp;A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. &nbsp;[Cover paper] Nature Feb 10, 2000; &nbsp;Vol. 403, 623-627.</div>
-
    <li style="margin-bottom: 0.1em;">Berka J, Chen YJ, Leamon JH, Lefkowitz S, Lohman KL, Makhijani VB, Rothberg JM, Sarkis GJ, Srinivasan M, Weiner MP. Bead Emulsion Nucleic Acid Amplification. USP# 7,842,457</li>
+
<div>Simpson JW, Ruiz-Martinez MC, Mulhern GT, Berka J, Latimer DR, Ball JA, Rothberg JM, Went GT. &nbsp; &nbsp;A transmission imaging spectrograph and microfabricated channel system for DNA analysis. &nbsp; &nbsp; &nbsp;Electrophoresis 2000; Vol. 21, 135-149.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg, JM, Bader JS, Dewell SB, McDade K, Simpson JW, Berka, Colangelo CM, Weiner, MP. Apparatus and Method for Sequencing a Nucleic Acid. USP# 7,335,762</li>
+
<div>Hammond RW, Bader JS, Henck SA, Deem MW, McDermott GA, Bustillo JM, Rothberg, JM. &nbsp; &nbsp;Differential transport of DNA by a rectified Brownian motion device. &nbsp;Electrophoresis 2000; Vol. 21, 74-80.</div>
-
    <li style="margin-bottom: 0.1em;">Leamon; JH., Lohman; KL., Rothberg; JM. &amp; Weiner MP. Methods of amplifying and sequencing nucleic acids; United States Patent 7,323,305 &amp; European Patent EP1590477</li>
+
<div>Bader J, Hammond R W, Henck SA, Deem MW, McDermott GA, Bustillo JM, Simpson JW, Mulhern GT, and Rothberg JM. &nbsp;DNA transport by a micromachined Brownian ratchet device. PNAS USA November 9, 1999; Vol. 96 No. 23. 13165-9.</div>
-
    <li style="margin-bottom: 0.1em;">Chen Y, Leamon JH, Lohman KL, Ronan MT, Rothberg JM, Srinivasan M, Weiner MP. Double Ended Sequencing. USP# 7,244,567</li>
+
<div>Shimkets R A, Lowe DG, Tsu-Ning Tai J, Sehl P, Jin H, Yang R, Predki P, Rothberg BEG, Murtha MT, Roth ME, Shenoy SG, McKenna MP, Hillan K, Went GT, and Rothberg JM. Gene expression analysis by transcript profiling coupled to a gene database query [GeneCalling]. Nature Biotechnology August 1999; Vol. 17, 798-803.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Bader JS, Dewell SB, McDade K, Simpson JW, Berka J, Colangelo CM. Method of sequencing a nucleic acid. USP# 7,244,559</li>
+
<div>Rothberg JM, and Artavanis-Tsakonas S. Modularity of the Slit Protein. J. Mol. Biol. &nbsp;1992; 227, 367-370.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Bader JS, Dewell SB, McDade K, Simpson JW, Berka J, Colangelo CM. Method of sequencing a nucleic acid. USP# 7,211,390.</li>
+
<div>Rothberg JM. Gene Patents. Nature 1992; 356, 738.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Deem MW, Simpson JW. Detection and confirmation of nucleic acid sequences by use of poisoning oligonucleotides. USP# 6,673,577.</li>
+
<div>Rothberg JM Ph.D. slit: an Extracellular Protein Necessary for the Development of Midline Glia and Axon Pathways of the Central Nervous System contains both EGF and Flank-LRR-Flank Domains. Thesis, Yale University, 1991.</div>
-
    <li style="margin-bottom: 0.1em;">Simpson JW, Rothberg JM, Went, GT, Ruiz-Martinez MC, Mulhern GT. Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP# 6,485,625.</li>
+
<div>Rothberg JM, Jacobs J R, Goodman CS and Artavanis-Tsakonas S. slit: An Extracellular Protein Necessary for Development of Midline Glia and Commissural Axon Pathways Contains both EGF and LRR Domains. Genes &amp; Development 1990; 4, 2169-2187.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,453,245</li>
+
<div>Rothberg JM, Hartley DA, Walther Z, and Artavanis-Tsakonas S. slit: An EGF-Homologous Locus of D. melanogaster Involved in the Development of the ➞Embryonic Central Nervous System. &nbsp;[Cover paper] Cell 1988; 55, 1047-1059.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,432,361</li>
+
<div>Issued U.S. Patents</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,418,382</li>
+
<div>&nbsp;</div>
-
    <li style="margin-bottom: 0.1em;">Nandabalan K, Rothberg JM, Yang M, Knight JR, Kalbfleisch TS. Identification and comparison of protein&mdash;protein interactions that occur in populations and identification of inhibitors of these interactors. USP# 6,410,239.</li>
+
<div>Rothberg J, Wolfgang H, Johnson K, Bustillo J, Methods and apparatus for measuring analytes using large scale FET arrays. &nbsp;USP# 7,948.015</div>
-
    <li style="margin-bottom: 0.1em;">Nandabalan K, Rothberg JM. Identification and comparison of protein-protein interactions that occur in populations and identification of inhibitors of these interactors. USP# 6,395,478.</li>
+
<div>Berka J, Chen YJ, Leamon JH, Lefkowitz S, Lohman KL, Makhijani VB, Rothberg JM, Sarkis GJ, Srinivasan M, Weiner MP. Bead Emulsion Nucleic Acid Amplification. &nbsp;USP# 7,842,457</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Nallur GN, Hu X. Methods and devices for measuring differential gene expression. USP# 6,355,423.</li>
+
<div>Rothberg, JM, Bader JS, Dewell SB, McDade K, Simpson JW, Berka, Colangelo CM, Weiner, MP. Apparatus and Method for Sequencing a Nucleic Acid. USP# 7,335,762</div>
-
    <li style="margin-bottom: 0.1em;">Deem MW, Rothberg JM, Went GT. Consensus configurational bias Monte Carlo method and system for pharmacophore structure determination. USP# 6,341,256.</li>
+
<div>Leamon; JH., Lohman; KL., Rothberg; JM. &amp; Weiner MP. Methods of amplifying and sequencing nucleic acids; United States Patent 7,323,305 &amp; European Patent EP1590477</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Bader JS. Method of sequencing a nucleic acid. USP # 6,274,320.</li>
+
<div>Chen Y, Leamon JH, Lohman KL, Ronan MT, Rothberg JM, Srinivasan M, Weiner MP. Double Ended Sequencing. USP# 7,244,567</div>
-
    <li style="margin-bottom: 0.1em;">Simpson JW, Rothberg JM, Went GT. Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP # 6,236,945.</li>
+
<div>Rothberg JM, Bader JS, Dewell SB, McDade K, Simpson JW, Berka J, Colangelo CM. Method of sequencing a nucleic acid. USP# 7,244,559</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Deem MW, Simpson JW. Method and apparatus for identifying, classifying, or quantSimpson JW, Rothberg JM, Went GT. Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP # 6,218,121.</li>
+
<div>Rothberg JM, Bader JS, Dewell SB, McDade K, Simpson JW, Berka J, Colangelo CM. Method of sequencing a nucleic acid. USP# 7,211,390.</div>
-
    <li style="margin-bottom: 0.1em;">Bader JS, Rothberg JM, Deem MW, Mulhern GT, Went GT, Simpson JW, Henck S. Separation of charged particles by a spatially and temporally varying electric field. USP # 6,193,866.</li>
+
<div>Rothberg JM, Deem MW, Simpson JW. Detection and confirmation of nucleic acid sequences by use of poisoning oligonucleotides. USP# 6,673,577.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Deem MW, Simpson JW. Method for identifying a nucleic acid sequence. USP # 6,190,868.</li>
+
<div>Simpson JW, Rothberg JM, Went, GT, Ruiz-Martinez MC, Mulhern GT. &nbsp;Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP# 6,485,625.</div>
-
    <li style="margin-bottom: 0.1em;">Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,141,657.</li>
+
<div>Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,453,245</div>
-
    <li style="margin-bottom: 0.1em;">Nandabalan K, Rothberg JM. Identification and comparison of protein-protein interactions that occur in populations. USP # 6,083,693.</li>
+
<div>Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,432,361</div>
-
    <li style="margin-bottom: 0.1em;">Nandabalan K, Rothberg JM, Yang M, Knight JR, Kalbfleisch TS. Identification and comparison of protein-protein interactions that occur in populations and identification of inhibitors of these interactors. USP # 6,057,101.</li>
+
<div>Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,418,382</div>
-
    <li style="margin-bottom: 0.1em;">Simpson JW, Rothberg JM, Went GT. Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP # 6,017,434.</li>
+
<div>Nandabalan K, Rothberg JM, Yang M, Knight JR, Kalbfleisch TS. Identification and comparison of protein&mdash;protein interactions that occur in populations and identification of inhibitors of these interactors. USP# 6,410,239.</div>
-
    <li style="margin-bottom: 0.1em;">Simpson JW, Went GT and Rothberg JM. Apparatus and Method for the Generation, Separation, Detection and Recognition of Biopolymer Fragments. USP # 5,993,634.</li>
+
<div>Nandabalan K, Rothberg JM. Identification and comparison of protein-protein interactions that occur in populations and identification of inhibitors of these interactors. USP# 6,395,478.</div>
-
    <li style="margin-bottom: 0.1em;">Simpson JW, Went GT, and Rothberg JM. Apparatus and Method for the Generation, Separation, Detection and Recognition of Biopolymer Fragments. USP #5,972,693.</li>
+
<div>Rothberg JM, Nallur GN, Hu X. Methods and devices for measuring differential gene expression. &nbsp;USP# 6,355,423.</div>
-
    <li style="margin-bottom: 0.1em;">Bader J, Rothberg JM, Deem MW, Mulhern GT and Went GT. Nano Niagara Separation of Charged Particles by a Spatially and Temporally varying Electric Field. USP #5,938,904.</li>
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<div>Deem MW, Rothberg JM, Went GT. Consensus configurational bias Monte Carlo method and system for pharmacophore structure determination. USP# 6,341,256.</div>
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    <li style="margin-bottom: 0.1em;">Rothberg JM, Went GT, and Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP #5,871,697.</li>
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<div>Rothberg JM, Bader JS. Method of sequencing a nucleic acid. USP # 6,274,320.</div>
-
</ol>
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<div>Simpson JW, Rothberg JM, Went GT. Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP # 6,236,945.</div>
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<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="References">References</span><span class="mw-editsection mw-editsection-expanded" style="-webkit-user-select: none; font-size: small; margin-left: 1em; vertical-align: baseline; line-height: 1em; display: inline-block; white-space: nowrap; padding-right: 0.25em; unicode-bidi: -webkit-isolate; direction: ltr;"><span class="mw-editsection-bracket" style="margin-left: -0.25em; margin-right: 0.25em; color: rgb(85, 85, 85);">[</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;action=edit&amp;section=15&amp;editintro=Template:BLP_editintro" title="Edit section: References" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit source</a><span class="mw-editsection-divider" style="color: rgb(85, 85, 85);">&nbsp;|&nbsp;</span><a href="http://en.wikipedia.org/w/index.php?title=Jonathan_M._Rothberg&amp;veaction=edit&amp;section=15&amp;editintro=Template:BLP_editintro" title="Edit section: References" class="mw-editsection-visualeditor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">edit<span class="ve-tabmessage-appendix" style="font-size: 0.7em; vertical-align: top; line-height: 1.43em; padding-left: 0.5em; background-image: none !important; display: inline !important;">beta</span></a><span class="mw-editsection-bracket" style="margin-right: -0.25em; margin-left: 0.25em; color: rgb(85, 85, 85);">]</span></span></h2>
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<div>Rothberg JM, Deem MW, Simpson JW. Method and apparatus for identifying, classifying, or quantSimpson JW, Rothberg JM, Went GT. Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP # 6,218,121.</div>
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<div class="reflist references-column-count references-column-count-2" style="font-size: 11.199999809265137px; margin-bottom: 0.5em; font-family: sans-serif; line-height: 19.200000762939453px; -webkit-column-count: 2; list-style-type: decimal;">
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<div>Bader JS, Rothberg JM, Deem MW, Mulhern GT, Went GT, Simpson JW, Henck S. Separation of charged particles by a spatially and temporally varying electric field. USP # 6,193,866.</div>
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<ol class="references" style="line-height: 1.5em; margin: 0.3em 0px 0.5em 3.2em; padding: 0px; list-style-image: none; list-style-type: inherit;">
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<div>Rothberg JM, Deem MW, Simpson JW. Method for identifying a nucleic acid sequence. USP # 6,190,868.</div>
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    <li id="cite_note-CT_Medal_of_Technology-1" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_ref-CT_Medal_of_Technology_1-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">^</a></b></span>&nbsp;<span class="reference-text"><a rel="nofollow" class="external text" href="http://www.ctcase.org/medal_bios/rothberg.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2010 Connecticut Medal of Technology bio</a>&nbsp;at Connecticut Academy of Science and Engineering, ctcase.org</span></li>
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<div>Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,141,657.</div>
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    <li id="cite_note-CellDex_acquires_CuraGen-2" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_ref-CellDex_acquires_CuraGen_2-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">^</a></b></span>&nbsp;<span class="reference-text"><a rel="nofollow" class="external text" href="http://www.ctcase.org/medal_bios/rothberg.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">CellDex Therapeutics Press Release</a></span></li>
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<div>Nandabalan K, Rothberg JM. Identification and comparison of protein-protein interactions that occur in populations. USP # 6,083,693.</div>
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    <li id="cite_note-Bio-itworld-3" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_ref-Bio-itworld_3-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">^</a></b></span>&nbsp;<span class="reference-text"><a rel="nofollow" class="external text" href="http://www.bio-itworld.com/newsitems/2007/may/05-31-07-watson-genome" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Project Jim: Watson&rsquo;s Personal Genome Goes Public</a>&nbsp;at Bio-IT World.com</span></li>
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<div>Nandabalan K, Rothberg JM, Yang M, Knight JR, Kalbfleisch TS. Identification and comparison of protein-protein interactions that occur in populations and identification of inhibitors of these interactors. USP # 6,057,101.</div>
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    <li id="cite_note-NYT310507-4" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_ref-NYT310507_4-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">^</a></b></span>&nbsp;<span class="reference-text"><a rel="nofollow" class="external text" href="http://www.nytimes.com/2007/05/31/science/31cnd-gene.html?ex=1182139200&amp;en=8c707c4f99236dd0&amp;ei=5070" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Genome of DNA Pioneer Is Deciphered</a>&nbsp;at NYT.com, derived on May 31, 2007.</span></li>
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<div>Simpson JW, Rothberg JM, Went GT. Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP # 6,017,434.</div>
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    <li id="cite_note-JWatsonSequ-5" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_ref-JWatsonSequ_5-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">^</a></b></span>&nbsp;<span class="reference-text"><a rel="nofollow" class="external text" href="http://jimwatsonsequence.cshl.edu/cgi-perl/gbrowse/jwsequence/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">James Watson's Personal Genome Sequence</a></span></li>
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<div>Simpson JW, Went GT and Rothberg JM. Apparatus and Method for the Generation, Separation, Detection and Recognition of Biopolymer Fragments. USP # 5,993,634.</div>
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    <li id="cite_note-6" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_ref-6" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">^</a></b></span>&nbsp;<span class="reference-text"><a rel="nofollow" class="external text" href="http://www.nature.com/nature/journal/v444/n7117/abs/nature05336.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Analysis of one million base pairs of Neanderthal DNA</a>&nbsp;at Nature.com</span></li>
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<div>Simpson JW, Went GT, and Rothberg JM. Apparatus and Method for the Generation, Separation, Detection and Recognition of Biopolymer Fragments. USP #5,972,693.</div>
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    <li id="cite_note-7" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_ref-7" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">^</a></b></span>&nbsp;<span class="reference-text"><a rel="nofollow" class="external text" href="http://www.prnewswire.com/news-releases/genetics-entrepreneur-jonathan-rothberg-wins-ct-medal-of-technology-94071489.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Genetics Entrepreneur Jonathan Rothberg Wins CT Medal of Technology, May 18, PRNewswire</a></span></li>
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<div>Bader J, Rothberg JM, Deem MW, Mulhern GT and Went GT. Nano Niagara Separation of Charged Particles by a Spatially and Temporally varying Electric Field. USP #5,938,904.</div>
-
    <li id="cite_note-8" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_ref-8" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">^</a></b></span>&nbsp;<span class="reference-text"><span class="citation web" style="word-wrap: break-word;"><a rel="nofollow" class="external text" href="http://articles.courant.com/2009-10-10/business/hc-curagen.artoct10_1_dr-timothy-shannon-celldex-therapeutics-tiny-unit" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">&quot;A Smaller CuraGen Corp. To Stay Open In Branford&quot;</a>.</span></span></li>
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<div>Rothberg JM, Went GT, and Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP #5,871,697.</div>
-
    <li id="cite_note-ion_torrent-9" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/Jonathan_M._Rothberg#cite_ref-ion_torrent_9-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; background-position: initial initial; background-repeat: initial initial;">^</a></b></span>&nbsp;<span class="reference-text"><a rel="nofollow" class="external text" href="http://www.iontorrent.com/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Ion Torrent Official Webpage.</a></span></li>
+
<div>References</div>
-
</ol>
+
<div>&nbsp;</div>
-
</div>
+
<div>&uarr; 2010 Connecticut Medal of Technology bio at Connecticut Academy of Science and Engineering, ctcase.org</div>
 +
<div>&uarr; CellDex Therapeutics Press Release</div>
 +
<div>&uarr; Project Jim: Watson&rsquo;s Personal Genome Goes Public at Bio-IT World.com</div>
 +
<div>&uarr; Genome of DNA Pioneer Is Deciphered at NYT.com, derived on May 31, 2007.</div>
 +
<div>&uarr; James Watson's Personal Genome Sequence</div>
 +
<div>&uarr; Analysis of one million base pairs of Neanderthal DNA at Nature.com</div>
 +
<div>&uarr; Genetics Entrepreneur Jonathan Rothberg Wins CT Medal of Technology, May 18, PRNewswire</div>
 +
<div>&uarr; &quot;A Smaller CuraGen Corp. To Stay Open In Branford&quot;.</div>
 +
<div>&uarr; Ion Torrent Official Webpage.</div>
 +
<div>&nbsp;</div>

Revision as of 01:08, 25 August 2013

Jonathan M. Rothberg (born 1963) is an American scientist and entrepreneur.
 
Early life
 
Jonathan was born in New Haven, Connecticut the son of Lillian and Dr. Henry Rothberg a chemical engineer.  Prior to Jonathan's birth, Lillian and Dr. Henry Rothberg founded Laticrete International, Inc. a family-owned, global manufacturer of products for the installation of tile and stone.  Jonathan's family established the foundation for his scientific career; early on, he was heavily influenced by his father's engineering background and problem solving abilities, as well as his mother's belief that he would "do good science."[1]
 
Education and scientific career
 
INSTITUTION AND LOCATION
 
DEGREE
 
YEAR
 
FIELD OF STUDY
 
Yale University, New Haven, CT
 
Ph.D.
 
1991
 
Biology
 
Yale University, New Haven, CT
 
M.Phil.
 
1988
 
Biology
 
Yale University, New Haven, CT
 
M.S.
 
1987
 
Biology
 
Carnegie Mellon University, Pittsburgh, PA
 
B.S.
 
1985
 
Chemical Engineering –  option in Biomedical Engineering
 
Rothberg earned a B.S. in Chemical Engineering with an option in Biomedical Engineering from Carnegie Mellon University, Pittsburgh, PA in 1985.  After completing college at Carnegie Mellon, Jonathan went on to attend Yale University and earn a M.S., M.Phil., and Ph.D. in biology.  His thesis at Yale focused on decoding a gene called slit responsible for wiring the nervous system.  Jonathan's thesis work resulted in publication of a cover article in the journal Cell in 1988. ↵While a graduate student at Yale Jonathan founded CuraGen, one of the first genomics companies (CellDex Therapeutics acquired CuraGen in fall of 2009).[2]  At CuraGen, Jonathan and his team focused on how the proteins encoded in a genome function together, and published the first global proteomic maps of a eukaryotic cell and a metazoan organism (featured on the covers of Nature and Science) and developed drugs for the treatment of metastatic skin and breast cancer.
 
Rothberg brought to market the first next-generation sequencer and has been a pioneering entrepreneur in the field of massively parallel DNA sequencing[citation needed]. He founded 454 Life Sciences Corporation, later acquired by Roche Diagnostics, and Ion Torrent, companies that have commercialized technologies for DNA sequencing that have significantly reduced the cost of sequencing a genome. His team at 454 Life Sciences and the Baylor College of Medicine Genome Center was the first to complete and make public the sequence of an individual human genome (James D. Watson[3][4]). Published in Nature magazine, that genome was made publicly on GenBank and browsable via the efforts of Lincoln Stein's group [5] contributing significantly to the new field of personal genomics.  Rothberg also initiated the Neanderthal Genome Project in collaboration with Svante Pääbo's group.[6]
 
Under his tenure, 454 Life Sciences worked with collaborators to crack the mystery behind the disappearance of the honey bee, uncover a new virus killing transplant patients, and elucidate the extent of individual human variation—work recognized by Science magazine as the breakthrough of the year for 2007. The collective work of Dr. Rothberg's team, their collaborators and ultimately their customers, included projects as diverse as uncovering the complexity of life in the World's oceans and sequencing the extinct wooly mammoth.
 
The New England Journal described Dr. Rothberg’s sequencing innovation as "The New Age of Molecular Diagnostics for Microbial Agents." Science magazine called it one of the top 10 breakthroughs for 2008. Dr. Rothberg has appeared on CNBC, CNN, and Bloomberg TV for his pioneering work in the field of genomic medicine, has been featured on the cover of Fortune magazine, and his scientific work has been featured on the covers of leading scientific journals including Cell, Science, and Nature. His contribution to sequencing, include both the first non-bacterial cloning systems (cloning by limited dilution), as well as the first massively parallel DNA sequencing method (sequencing by synthesis on a single substrate in parallel), concepts that have formed the basis for all subsequence next generation sequencing technologies.
 
Rothberg is a member of the National Academy of Engineering, the Connecticut Academy of Medical Science and Engineering, and is a life of trustees of Carnegie Mellon University.
 
Positions and honors
 
Positions
2007–2013 Founder, CEO and Chairman of the Board, Ion Torrent, Inc., Guilford, CT
2005–Present  Board of Trustees, Carnegie Mellon University, Pittsburgh, PA
2004–Present  Co-Founder, Founding CEO, Chairman, RainDance Technologies, Inc., Guilford, CT
2001–Present  Founder, Chairman of the Board, Rothberg Institute for Childhood Diseases, Guilford, CT
2000-2007  Founder, Founding CEO, Chairman of the Board, 454 Life Sciences, Branford, CT
1999-2007  Co-Founder, Chairman of the Board, Clarifi, Boca Raton
1998–Present  Board Member, Connecticut United for Research Excellence (CURE), New Haven, CT
1993-2005  Founder, CEO, President, and Chairman of the Board, CuraGen Corporation, Branford, CT
1991-1993  Post-Doctoral Fellow, Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, New Haven, CT
Honors and awards
2011 CBA Brilliant Achievement Award
2011 DGKL Biochemical Analysis Prize for development of massively parallel DNA               sequencing
2011 Doctor of Science Honoris Causa Mount Sinai School of Medicine
2010 The World Economic Forum’s Technology Pioneer (First person to be awarded three times)
2010  Connecticut Medal of Technology[7]
2008 The World Economic Forum’s Technology Pioneer
2007 The World Economic Forum’s Technology Pioneer
2006 R & D 100 Awards for 454 Life Sciences
2005 Wall Street Journal 2005 Technology Innovation Awards, Gold Medal Winner
2005  Connecticut Academy of Science and Engineering
2004  National Academy of Engineering
2000  The Irvington Institute’s Corporate Leadership Award in Science
1998  Ernst and Young Entrepreneur of the Year
1991  John Spangler Nicholas Prize for the outstanding Doctoral candidate in Experimental Zoology
1985-1989  National Research Service Award, National Institutes of Health
Professional memberships
2004-2008  Member, Young Presidents’ Organization↵National Academy of Engineering↵Connecticut Academy of Medical Science and Engineering↵Carnegie Mellon University Board of Trustees
 
Companies
 
CuraGen
In 1991, Rothberg founded New Haven-based CuraGen, one of the first companies to develop drugs based on genomics. While at CuraGen, he developed a series of new medicines, in over 14 human clinical trials, for the treatment of a wide range of cancers. CuraGen however never released any drug to market.[8]
 
454 Life Sciences
In 1999, Rothberg founded 454 Life Sciences, based in Branford (CT), which pioneered an entirely new way to sequence genomes.
 
Ion Torrent
Rothberg founded Ion Torrent in 2007, who developed ion semiconductor sequencing which is utilized by their PGM DNA sequencer.[9]
 
Rothberg Center for Childhood diseases
Rothberg is a founder of the Rothberg Center for Childhood diseases.
 
RainDance Technologies
Founded first company to use droplet based microfluidics
 
Selected Publications
 
Rothberg, J.M. et al., An integrated semiconductor device enabling non-optical genome sequencing. Nature 475, July 2011. 348-352.
Alexander Mellmann., Dag Harmsen., Craig A. Cummings., Emily B. Zentz, Shana R. Leopold, Alain Rico, Karola Prior, Rafael Szczepanowski, Yongmei Ji, Wenlan Zhang, Stephen F. McLaughlin, John K. Henkhaus, Benjamin Leopold, Martina Bielaszewska, Rita Prager, Pius M. Brzoska, Richard L. Moore, Simone Guenther, Jonathan M. Rothberg, Helge Karch. Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology. PLOS one, Volume 6, Issue 7, July 2011.
E. Brouzes, M. Medkova, N Savenelli, D. Marran, M. Twardowski, J. B. Hutchinon, J. J. M. Rothberg, D.R. Link, N. Perrimon, M. L. Samuels.  Droplet microfluidic technology for single-cell high thoughput screening. PNAS, July  2009, Vol. 106, no. 106
Birgitte B. Simen, Jan Fredrik Simons, Katherine Huppler Hullsiek,,Richard M. Novak, Rodger D. MacArthur, John D. Baxter, Chunli Huang,,Christine Lubeski, Gregory S. Turenchalk, Michael S. Braverman, Brian Desany, Jonathan M. Rothberg, Michael Egholm, Michael J. Kozal. Low-Abundance Drug-Resistant Viral Variants in Chronically HIV-Infected, Antiretroviral Treatment-Naïve Patients Significantly Impact Treatment Outcomes. The Journal of Infectious Diseases. 2009; 199:693-701.
Richard E Green, Anna-Sapfo Malaspinas, Johannes Krause, Adrian W Briggs, Philip L F Johnson, Caroline Uhler, Matthias Meyer, Jeffrey M Good, Tomislav Maricic, Udo Stenzel, Kay Prüfer, Michael Siebauer, Hernán A Burbano, Michael Ronan, Jonathan M Rothberg, Michael Egholm, Pavao Rudan, Dejana Brajković, Zeljko Kućan, Ivan Gusić, Mårten Wikström, Liisa Laakkonen, Janet Kelso, Montgomery Slatkin, Svante Pääbo. A complete neandertal mitochondrial genome sequence determined by high-throughput sequencing.  [Cover Paper] Cell. 2008 Aug 8;134 (3):416-26
David A Wheeler, Maithreyan Srinivasan, Michael Egholm, Yufeng Shen, Lei Chen, Amy McGuire, Wen He, Yi-Ju Chen, Vinod Makhijani, G Thomas Roth, Xavier Gomes, Karrie Tartaro, Faheem Niazi, Cynthia L Turcotte, Gerard P Irzyk, James R Lupski, Craig Chinault, Xing-Zhi Song, Yue Liu, Ye Yuan, Lynne Nazareth, Xiang Qin, Donna M Muzny, Marcel Margulies, George M Weinstock, Richard A Gibbs, Jonathan M Rothberg.  The complete genome of an individual by massively parallel DNA sequencing. Nature 2008 Apr 17;452 (7189):872-6
John H. Leamon, Michael S. Braverman and Jonathan M. Rothberg. High-Throughput, Massively Parallel DNA Sequencing Technology for the Era of Personalized Medicine? Gene Therapy and Regulation, 2007, vol. 2, no. 1, 15-31.
John H. Leamon and Jonathan M. Rothberg. Cramming More Sequencing Reactions onto Microreactor Chips. Chemical Reviews, 2007 Aug; 107(8):3367-76.
Green, R.E., Krause, J., Ptak, S.E., Briggs, A.W., Ronan, M., Simons, J.F., Egholm, M., Rothberg, J., Paunovic, M., and Pääbo, S.: Analysis of one million base pairs of Neandertal DNA. [Cover Paper] Nature 444, 330-336.16 November 2006
Robert Pinard, Alex de Winter, Gary J Sarkis, Mark B Gerstein, Karrie R Tartaro, Ramona N Plant, Michael Egholm, Jonathan M Rothberg, and John H Leamon. Assessment of whole genome amplification-induced bias through high-throughput, massively parallel whole genome sequencing. BMC Genomics. 2006; 7: 216. Published online 2006 August 23.
Stiller, M., Green, R.E., Ronan, M., Simons, J.F., Du, L., He, W., Egholm, M., Rothberg, J., Keates, S.G., Ovodov, N.D., Antipina, E.E., Baryshnikov, G.F., Kuzmin, Y.V., Vasilevski, A.A., Wuenschell, G.E., Termini, J., Hofreiter, M., Jaenicke-Després, V., and Pääbo, S.: Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA. PNAS, September 12, 2006, vol. 103, no. 37, 13578-13584.
Thomas RK, Nickerson E, Simons JF, Janne PA, Tengs T, Yuza Y, Garraway LA, Laframboise T, Lee JC, Shah K, O'neill K, Sasaki H, Lindeman N, Wong KK, Borras AM, Gutmann EJ, Dragnev KH, Debiasi R, Chen TH, Glatt KA, Greulich H, Desany B, Lubeski CK, Brockman W, Alvarez P, Hutchison SK, Leamon JH, Ronan MT, Turenchalk GS, Egholm M, Sellers WR, Rothberg JM, Meyerson M.  Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing. Nat Med. 2006 Jul;12(7):852-855.
Leamon JH, Link DR, Egholm M, Rothberg JM. Overview: methods and applications for droplet compartmentalization of biology. Nat Methods. 2006 Jul;3(7):541-3.
Thomas RK, Greulich H, Yuza Y, Lee JC, Tengs T, Feng W, Chen TH, Nickerson E, Simons J, Egholm M, Rothberg JM, Sellers WR, and Meyerson ML. Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors. Cold Spring Harb Symp Quant Biol. 2005; 70: 73-81.
Margulies M, Egholm M, Altman WE, Attiya S, Bader JS, Bemben LA., Berka J, Braverman MS, Chen YJ, Chen Z, Dewell SB, de Winter A, Drake J, Du L, Fierro JM, Forte R, Gomes XV, Godwin BC, He W, Helgesen S, Ho CH, Hutchison SK, Irzyk GP, Jando SC, Alenquer MLI, Jarvie TP, Jirage KB, Kim JB, Knight JR, Lanza JR, Leamon JH, Lee WL, Lefkowitz SM, Lei M, Li J, Lohman KL, Lu H, Makhijani VB, McDade KE, McKenna MP, Myers EW, Nickerson E, Nobile JR, Plant R, Puc BP, Reifler M Ronan MT, Roth GT, Sarkis GJ, Simons JF, Simpson JW, Srinivasan M, Tartaro KR, Tomasz A, Vogt KA, Volkmer GA, Wang SH, Wang Y, Weiner MP, Willoughby DA, Yu P, Begley RF, Rothberg JM.  Genome sequencing in microfabricated high-density picolitre reactors.    Nature 2005; 441.7089.
Gunther EC, Stone DJ, Rothberg JM, and Gerwien RW. A quantitative genomic expression analysis platform for multiplexed in vitro prediction of drug action. The Pharmacogenomics Journal 5, 2005, 126-134.
Gould Rothberg BE, Pena CEA, Rothberg JM.    A systems biology approach to target identification and validation for human chronic disease drug discovery. Division of Chronic Disease Epidemiology, Yale University School of Public Health. Modern Biopharmaceuticals 2005; 1 99-125.
Bader JS, Chaudhuri A. Rothberg JM, and Chant J. Gaining confidence in high-throughput protein interaction networks. Nature Biotechnology 2003; 10.1038.
Leamon JH, Lee WL, Tartaro KR Lanza JR, Sarkis GJ, deWinter AD, Berka J, Weiner M, Rothberg JM, Lohman KL. A massively parallel PicoTitlerPlate based platform for discrete picoliter-scale polymerase chain reactions. Electrophoresis 24(21). November 2003:3769-77, Erratum in Eletrophoresis.25 1176 April 204: 7-8.
Giot L, Bader JS, Brouwer C, Chaudhuri A, Kuang B, Li Y, Hoa YL, Oi CE, Godwin G, Vitols E, Vijayadamodar G, Pochart P, Machineni H, Welsh, M, Kong Y, Zerhusen B, Malcolm R, Varrone Z, Collis A, Minto M, Burgess S, McDaniel L, Stimpson E, Springs F, Williams J, Neurath K, Ioime N, Agee M, Voss E, Furkat K, Renzulli R, Aanensen N, Carrolla S, Bickelhaupt E, Lazovatsky Y, DaSilva A, Zhong J, Stanyon CA, Finley Jr RL, White KP, Braverman M, Jarvie T, Gold S, Leach M, Knight J, Shimkets RA, McKenna MP, Chant J, and Rothberg JM. Protein Interaction Map of Drosophila melanogaster. [Cover paper] Science November 2, 2003; 10.1126.
Bader JS, Deem MW, Hammond RW, Henck SA, Simpson JW, Rothberg JM. A Brownian-ratchet DNA pump with applications to single-nucleotide polymorphism genotyping. Applied Physics A: Materials Science & Processing. 2000; Vol. 75, 275-278.
Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K; Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF.    The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.  Molecular Medicine 2002; Vol. 8, 56-64.
LaRochelle WJ, Jeffers M, McDonald WF, Chillakuru RA, N Lokker NA, Sullivan C, Boldog FL, Yang, M, Vernet C, Burgess CE, Fernandes E, Deegler LL, Rittman B, Shimkets  J, Shimkets RA, Rothberg JM, and Lichenstein HS. PDGF-D, a new protease-activated growth factor. Nature Cell Biology May 1, 2001; Vol. 3. 517-521.
Herrmann J, Rastelli L, Brugess CE, Fernandes EE, Rothberg BEG, Rothberg JM, and Shimkets RA. Implications of Oncogenomics for Cancer Research and Clinical Oncology. The Cancer Journal. January/February 2001; Volume 7 Number 1.
Rothberg BEG, Sundseth SS, DiPippo VA, Brown PJ, Winegar DA, Gottshalk WK, Shenoy SG, and Rothberg JM. The characterization of PPARα ligand drug action in an in vivo model by comprehensive differential gene expression profiling. [Cover paper] Functional and Integrative Genomics. October 2000.
Uetz P, Giot L, Cagney G, Mansfield TA, Judson RS, Knight JR, Lockshon D, Narayan V, Sriivasan M, Pochart P, Qureshi-Emili A, Li Y, Godwin B, Conver D, Kalbfleisch T, Vijayadamodar G, Yang M, Johnston M, Fields S, and Rothberg JM.  A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae.  [Cover paper] Nature Feb 10, 2000;  Vol. 403, 623-627.
Simpson JW, Ruiz-Martinez MC, Mulhern GT, Berka J, Latimer DR, Ball JA, Rothberg JM, Went GT.    A transmission imaging spectrograph and microfabricated channel system for DNA analysis.      Electrophoresis 2000; Vol. 21, 135-149.
Hammond RW, Bader JS, Henck SA, Deem MW, McDermott GA, Bustillo JM, Rothberg, JM.    Differential transport of DNA by a rectified Brownian motion device.  Electrophoresis 2000; Vol. 21, 74-80.
Bader J, Hammond R W, Henck SA, Deem MW, McDermott GA, Bustillo JM, Simpson JW, Mulhern GT, and Rothberg JM.  DNA transport by a micromachined Brownian ratchet device. PNAS USA November 9, 1999; Vol. 96 No. 23. 13165-9.
Shimkets R A, Lowe DG, Tsu-Ning Tai J, Sehl P, Jin H, Yang R, Predki P, Rothberg BEG, Murtha MT, Roth ME, Shenoy SG, McKenna MP, Hillan K, Went GT, and Rothberg JM. Gene expression analysis by transcript profiling coupled to a gene database query [GeneCalling]. Nature Biotechnology August 1999; Vol. 17, 798-803.
Rothberg JM, and Artavanis-Tsakonas S. Modularity of the Slit Protein. J. Mol. Biol.  1992; 227, 367-370.
Rothberg JM. Gene Patents. Nature 1992; 356, 738.
Rothberg JM Ph.D. slit: an Extracellular Protein Necessary for the Development of Midline Glia and Axon Pathways of the Central Nervous System contains both EGF and Flank-LRR-Flank Domains. Thesis, Yale University, 1991.
Rothberg JM, Jacobs J R, Goodman CS and Artavanis-Tsakonas S. slit: An Extracellular Protein Necessary for Development of Midline Glia and Commissural Axon Pathways Contains both EGF and LRR Domains. Genes & Development 1990; 4, 2169-2187.
Rothberg JM, Hartley DA, Walther Z, and Artavanis-Tsakonas S. slit: An EGF-Homologous Locus of D. melanogaster Involved in the Development of the ➞Embryonic Central Nervous System.  [Cover paper] Cell 1988; 55, 1047-1059.
Issued U.S. Patents
 
Rothberg J, Wolfgang H, Johnson K, Bustillo J, Methods and apparatus for measuring analytes using large scale FET arrays.  USP# 7,948.015
Berka J, Chen YJ, Leamon JH, Lefkowitz S, Lohman KL, Makhijani VB, Rothberg JM, Sarkis GJ, Srinivasan M, Weiner MP. Bead Emulsion Nucleic Acid Amplification.  USP# 7,842,457
Rothberg, JM, Bader JS, Dewell SB, McDade K, Simpson JW, Berka, Colangelo CM, Weiner, MP. Apparatus and Method for Sequencing a Nucleic Acid. USP# 7,335,762
Leamon; JH., Lohman; KL., Rothberg; JM. & Weiner MP. Methods of amplifying and sequencing nucleic acids; United States Patent 7,323,305 & European Patent EP1590477
Chen Y, Leamon JH, Lohman KL, Ronan MT, Rothberg JM, Srinivasan M, Weiner MP. Double Ended Sequencing. USP# 7,244,567
Rothberg JM, Bader JS, Dewell SB, McDade K, Simpson JW, Berka J, Colangelo CM. Method of sequencing a nucleic acid. USP# 7,244,559
Rothberg JM, Bader JS, Dewell SB, McDade K, Simpson JW, Berka J, Colangelo CM. Method of sequencing a nucleic acid. USP# 7,211,390.
Rothberg JM, Deem MW, Simpson JW. Detection and confirmation of nucleic acid sequences by use of poisoning oligonucleotides. USP# 6,673,577.
Simpson JW, Rothberg JM, Went, GT, Ruiz-Martinez MC, Mulhern GT.  Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP# 6,485,625.
Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,453,245
Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,432,361
Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,418,382
Nandabalan K, Rothberg JM, Yang M, Knight JR, Kalbfleisch TS. Identification and comparison of protein—protein interactions that occur in populations and identification of inhibitors of these interactors. USP# 6,410,239.
Nandabalan K, Rothberg JM. Identification and comparison of protein-protein interactions that occur in populations and identification of inhibitors of these interactors. USP# 6,395,478.
Rothberg JM, Nallur GN, Hu X. Methods and devices for measuring differential gene expression.  USP# 6,355,423.
Deem MW, Rothberg JM, Went GT. Consensus configurational bias Monte Carlo method and system for pharmacophore structure determination. USP# 6,341,256.
Rothberg JM, Bader JS. Method of sequencing a nucleic acid. USP # 6,274,320.
Simpson JW, Rothberg JM, Went GT. Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP # 6,236,945.
Rothberg JM, Deem MW, Simpson JW. Method and apparatus for identifying, classifying, or quantSimpson JW, Rothberg JM, Went GT. Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP # 6,218,121.
Bader JS, Rothberg JM, Deem MW, Mulhern GT, Went GT, Simpson JW, Henck S. Separation of charged particles by a spatially and temporally varying electric field. USP # 6,193,866.
Rothberg JM, Deem MW, Simpson JW. Method for identifying a nucleic acid sequence. USP # 6,190,868.
Rothberg JM, Deem MW, Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP # 6,141,657.
Nandabalan K, Rothberg JM. Identification and comparison of protein-protein interactions that occur in populations. USP # 6,083,693.
Nandabalan K, Rothberg JM, Yang M, Knight JR, Kalbfleisch TS. Identification and comparison of protein-protein interactions that occur in populations and identification of inhibitors of these interactors. USP # 6,057,101.
Simpson JW, Rothberg JM, Went GT. Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments. USP # 6,017,434.
Simpson JW, Went GT and Rothberg JM. Apparatus and Method for the Generation, Separation, Detection and Recognition of Biopolymer Fragments. USP # 5,993,634.
Simpson JW, Went GT, and Rothberg JM. Apparatus and Method for the Generation, Separation, Detection and Recognition of Biopolymer Fragments. USP #5,972,693.
Bader J, Rothberg JM, Deem MW, Mulhern GT and Went GT. Nano Niagara Separation of Charged Particles by a Spatially and Temporally varying Electric Field. USP #5,938,904.
Rothberg JM, Went GT, and Simpson JW. Method and Apparatus for Identifying, Classifying, or Quantifying DNA Sequences in a Sample without Sequencing. USP #5,871,697.
References
 
↑ 2010 Connecticut Medal of Technology bio at Connecticut Academy of Science and Engineering, ctcase.org
↑ CellDex Therapeutics Press Release
↑ Project Jim: Watson’s Personal Genome Goes Public at Bio-IT World.com
↑ Genome of DNA Pioneer Is Deciphered at NYT.com, derived on May 31, 2007.
↑ James Watson's Personal Genome Sequence
↑ Analysis of one million base pairs of Neanderthal DNA at Nature.com
↑ Genetics Entrepreneur Jonathan Rothberg Wins CT Medal of Technology, May 18, PRNewswire
↑ "A Smaller CuraGen Corp. To Stay Open In Branford".
↑ Ion Torrent Official Webpage.
 
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